TUI will be axing 186 flights from Manchester Airport as thousands of passengers affected will be notified by the end of the day (May 31), said the carrier.
The cuts are a bid to manage staff shortages and 'ongoing disruption' that have also led to baggage problems and delays.
TUI said customers due to fly over the 'coming days' were notified last night, while the rest will be informed 'later today' by text or email.
Manchester Airport is understood to be the only hub in the country impacted by TUI's raft of cancellations, cutting six flights a day, 186 flights in total, between May 31 and June 30.
TUI has declined to answer a request by our sister site Manchester Evening News for a list of services impacted.
The cancellations will ruin the plans of around 34,000 holidaymakers, adding to the growing number of fliers whose travels have been scrapped.
The airline said all other airports in the UK are planned to operate as normal.
Meanwhile, the airport blamed staff shortages in both the TUI and Swissport operations, a problem which they say is blighting the travel industry more widely.
The hub issued a candid apology over its staffing crisis just last month.
The decision comes amid ongoing tales from travellers of missing luggage, holidays being cancelled by text and mammoth flight delays.
On Saturday, police were drafted in to tell 'hundreds' of people waiting at the boarding gate, following an eight-hour delay, that their flight to Kos in Greece had been cancelled.
TUI said in an earlier statement that the 'sudden increase' in people going on holiday combined with 'various operational and supply chain issues' had impacted a 'small number of flights'.
Meanwhile, Manchester Airport bosses had vowed to work with airlines and other handling agents experiencing difficulties amid an urgent recruitment drive, to resolve the ongoing issues for passengers.
However, TUI has now taken the decision to remove flights from its schedule in a bid to help resolve the crisis.
In a statement on Tuesday, TUI said: "We would like to apologise to our customers who have experienced flight delays and cancellations in recent days and understand that many of our customers have been looking forward to their holiday with us for a long time.
"Due to the amount of on-going disruption in our operation at Manchester Airport, we have made the incredibly difficult decision to cancel six flights a day (43 flights a week), from Tuesday, May 31, until Thursday, June 30. All other airports in the UK are planned to operate as normal.
"We understand how disappointing this will be for those impacted; however, we believe this is necessary to provide stability and a better customer service at Manchester Airport."
They concluded: "We will continue to work closely with all our airport partners and suppliers so we can provide the best possible holiday experience for our customers."
They said customers affected would receive a full refund for their holiday as well as an 'extra gesture of goodwill'. Customers impacted in the next 14 days will also receive information on how to apply for compensation in line with regulations.
TUI added: "We would like to reassure our customers that cancellations of this nature are extremely rare and would like to thank them for their patience and understanding.”
A Manchester Airport spokesman said: "Over the last few days TUI and its appointed ground handler, Swissport, have experienced significant challenges with their check-in and baggage reclaim operations at Manchester Airport. From extensive discussions with the TUI and Swissport management teams, it is clear that they are experiencing temporary staff shortages, in common with other aviation and travel companies."
They continued: "Given these challenges, we understand TUI’s difficult decision to cancel a number of services over the course of the next month, although we are obviously disappointed to see passengers’ plans disrupted in this way. We will continue to work with TUI, Swissport and other partners to give passengers the best possible service as the travel sector builds back to full strength after the pandemic.
"In the meantime, we continue to advise passengers to arrive three hours before their flight and to be as prepared as they can be for their journey through the airport."
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