Wales' Six Nations title hopes are all but over after a second defeat to England.
Of course, while disappointing that hopes of retaining their crown are effectively impossible at this stage, it does perhaps open things up selection-wise for Wayne Pivac.
Throw in the fact that a Six Nations fallow week has seen a number of Welsh internationals in action for their clubs and there's the potential for changes - with several arguably auditioning for a spot against France this weekend.
With that in mind, what's the likely XV going to be to take on France on Friday night?
Back-three: Liam Williams, Alex Cuthbert and Josh Adams
Starting with the back-three, it's hard to see any changes coming after Twickenham.
It probably wasn't Williams' finest performance, with the yellow card blotting his copybook, but he was solid under the high ball and is well-placed to keep hold of the 15 jersey.
As for the wings, Louis Rees-Zammit is undoubtedly working hard to force his way back into the reckoning - with a wonder try against Northampton for Gloucester helping his cause - but he'll likely be powerless on this occasion to usurp Cuthbert or Adams.
The former was back to his very best last week - looking like the strong and elusive runner who toured with the Lions in 2013 - while Adams remains a key figure in Wales' backline.
Midfield: Nick Tompkins and Owen Watkin
Much of this depends on how Watkin is faring after post-match testing - with the fact he returned following a head knock against England coming under intense scrutiny.
Presuming he is fit though, he seems likely to retain his place against France alongside Tompkins - who is quietly proving himself to be a reliable figure in the Welsh midfield.
For added measure, Tompkins was the best player on the park during Saracens' Premiership clash with Leicester this weekend - only strengthening his grip on that Welsh 12 jersey. You can read more about that here.
Were Watkin to miss out, then Jonathan Davies would be the man to bring experience into midfield.
It's hard to see Willis Halaholo forcing his way in. Even if it was hard to make much of an impression in a thrashing away to Ulster, the centre looked like he needed more minutes in a Cardiff jersey before he makes the step up to Test level again.
It's been a frustrating tournament as a whole for the hot-stepping 31-year-old - who could add a new dynamic to Wales' backline if he could just get out on the field amid Covid and injuries - but it now feels like this Six Nations may finally be a write-off for him.
Half-backs: Tomos Williams and Dan Biggar
There's almost certain to be no changes here.
Even if it's far from ideal for Pivac that Biggar is turning out for Northampton just six days before France, that's not going to have any bearing on selection.
Easily the first-choices in these positions.
In terms of back-up, Kieran Hardy has overtaken Gareth Davies as scrum-half cover - with Davies, not Hardy, being the man to return to the Scarlets this weekend.
While it seems likely that Gareth Anscombe will take on the bench spot ahead of Callum Sheedy, especially as Anscombe hasn't had to return to club duty this weekend unlike the Bristol Bears playmaker.
Win Wales v France tickets and watch Six Nations game for free:
You can also fill in the entry form and sign up to our newsletter here.
Front-row: Wyn Jones, Ryan Elias and Tomas Francis
There's been the odd bit of chatter about Wales ditching their current props and looking to players more adept in the loose.
Sure, there are perhaps players in the Wales squad that perhaps don't scrummage as well as Jones and Francis, but offer a breakdown or carrying threat.
Of course, props earn their crust from the set-piece - but that cliche aside, the clearout work done by Jones and Francis is crucial, given Wales still seem a little unsure of some of their roles in the attacking shape.
As for Elias, even if the lineout didn't quite go as well as hoped at Twickenham, he's still pretty much guaranteed to start at hooker.
Second-row: Will Rowlands and Adam Beard
There's no real debate here.
Alun Wyn Jones is back around the Wales camp rehabilitating from injury, but regardless of where he is fitness-wise, Wales may be best served not calling upon Test rugby's most-capped player for the remainder of this tournament.
Will Rowlands has grown into a starting role well, providing a willing carrier and work-horse to the engine room, while Adam Beard's own progress as a leader would only be curtailed by bringing Jones back into the fold.
Add in the fact that Seb Davies has shown some nice touches off the bench and it makes more sense for Pivac to stick with developing fresh locks after losing so many in recent years.
Back-row: Taine Basham, Jac Morgan and Taulupe Faletau
Ross Moriarty hasn't done much wrong in the Six Nations, other than probably concede a few too many penalties against Scotland and England, but Pivac could be tempted to change his back-row up for the visit of France.
Josh Navidi, who has now been called up, could well come back into the starting XV to bolster Wales' breakdown efficiency.
However, just one game back for Cardiff might mean a Test return is a little too soon. In truth, just like Halaholo, he just needs more time at club level.
If so, we could see Pivac move Basham, who continues to shine on an explosive level, to blindside - allowing Jac Morgan to come into the side for his breakdown expertise.
With Taulupe Faletau nailed on to get the No. 8 jersey after his tireless performance at Twickenham, there's an argument that this back-row perhaps lacks a little physicality.
But it would make up for that department in breakdown nous - with the feeling being that Wales need to find a space for Morgan after his introduction helped improve matters on the pitch against England.
Were either Basham or Moriarty to miss out though, you'd more than understand either player feeling hard done by.
Spare a thought for two of Wales' starters in Dublin - Aaron Wainwright and Ellis Jenkins.
Such is the back-row depth that they've gone backwards in the pecking order, with Jenkins now released from the squad.
