Jurgen Klopp says Liverpool will be without Joel Matip and probably Thiago Alcantara for Saturday's Premier League clash at home to West Ham.
Centre-back Matip was rested for Wednesday's FA Cup win at home to Norwich City, but he has since picked up an illness.
Thiago was forced out of last Sunday's Carabao Cup final with a hamstring injury he sustained in the warm-up, and although it isn't thought to be too serious he is likely to sit out the visit of David Moyes' men.
Klopp added that Curtis Jones, who was taken off at half-time against Norwich, and Naby Keita, who picked up an injury at Wembley, are also uncertain to face the Hammers.
"Pretty sure Thiago is not available," Klopp told his press conference on Friday.
"Curtis is not bad but good enough for tomorrow? We’ll see. Matip is ill, not Covid.”
On Keita, the German added that he "didn't know" if the midfielder would make it.
Meanwhile Roberto Firmino is set to return to training on Sunday, putting him in contention to face Inter Milan on Tuesday.
Liverpool go into the West Ham game second in the Premier League and six points behind leaders Manchester City, who face Manchester United on Sunday.
Having lifted the Carabao Cup and progressed in the FA Cup, the growing talk of a quadruple isn't affecting the club according to the German.
“The physical part is tough. The big challenge is (to keep fresh), " said Klopp.
"We had to change (10 players) Wednesday but came through, and we're now playing again three days later against a top class team.
"From a mental point of view, we make a decision; we want to be as successful as possible.”
On his team selection headache he added: “I am long enough to know how I want my team to play.
"The real problem was the squad for the final because five subs was great.
"It helps football, an intense game v Chelsea. We have to discuss that until it happens because it’s so necessary.”
Meanwhile defender Ibrahima Konate, who is likely to deputise for Matip on Saturday, has opened up on the task of maintaining a place in the Liverpool side and not getting too down when he doesn't play.
“Imagine, OK you are angry, you are sad, but two days after you have to play and you are not ready in your head and then you do a bad game,” the defender told Liverpoolfc.com.
“This would be like you saying to the coach: ‘Yes, I know why I don’t play.’
“You have to be ready every time and if you play [well], you put some problems in the head of the coach and this is good for the group and for you.
“After, if you don’t play, it’s you against you because OK, you will speak with the coach [and ask] why you don’t play and he will explain to you, but this will not change [anything].
“Then you have to fight, you have to work more and if you don’t play you have to think and ask yourself [why].
“If you have the answer to your question, you work on this and this and this, and after your time will be coming. With the work, your time will be coming, for sure."
