Runcorn's Guinness facility will receive £16m investment from Diageo - the owner of the Irish stout brand.
Diageo will use the money to "significantly upgrade" its bottling line and expand warehousing capacity at the packaging site. The investment will also be used to support the growth of Guinness Draught and Guinness Zero.
The Runcorn packaging plant marked its 50th anniversary in 2020. There are around 200 employees on the 18-acre site and it operates on a 24/7 basis, reports BusinessLive.
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As well as investing in Runcorn, the group also announced a further £24.5m would be spent on more than doubling the canning production at its Belfast base.
The company said: "Diageo is making the investment to meet global demand for Guinness products from domestic and export markets, with the expansion set to support accelerated production and product innovation. It will enhance efficiency and competitiveness at both sites. Construction is set to begin immediately with capacity at both facilities expected to come online in 2023."
Aidan Crowe, operations director for beer at Diageo, added: "This expansion is a significant investment in the development of our packaging facilities. The projects in Belfast and Runcorn will support our growth ambitions, helping us to deliver end-to-end product innovation, and reinforce our agility to meet demand and provide excellent service to our customers around the world."