At least 38 Palestinians have died in an Israeli airstrike on Khan Younis in southern Gaza, health officials said.
The strike hit a residential building in the al-Manara neighbourhood on Friday, according to Palestinian news agency Wafa. Children are reportedly among the dead, with dozens more wounded.
Rescue workers are currently searching through debris at the scene, where residential buildings have been reduced to rubble.
In one striking image, a man in a blue shirt is seen emerging from the wreckage, surrounded by concrete fragments from what appears to be a collapsed structure.
Another photograph from the scene shows several people surveying a landscape of crushed buildings and scattered personal belongings.
Trees and damaged residential buildings can be seen silhouetted against the sky, while household items and clothing lie strewn among the debris.
It comes after Israel's military chief has said there is a possibility for a "sharp conclusion" to the conflict with the Hezbollah militia in Lebanon.
"In the north, there's a possibility of reaching a sharp conclusion. We thoroughly dismantled Hezbollah's senior chain of command," chief of the general staff Herzi Halevi said in a statement from the Gaza Strip.
His comments came after the US Secretary of State, Antony Blinken, said the US did not want a protracted Israeli campaign in Lebanon, a month into Israel's onslaught against the heavily armed Iranian-backed Lebanese militia.
Mr Blinken also said he hoped Iran was getting a clear message that any further attacks on Israel fundamentally risked its own interests, with the region awaiting the retaliation Israel has vowed for an Iranian missile barrage on October 1.
US and Israeli negotiators will gather in Doha to prepare the way for renewed talks on a Gaza ceasefire deal, which would also entail the release of hostages in Gaza, senior Qatari and US diplomats said.
Mr Blinken, speaking after talks with Qatar's prime minister, said it had not yet been determined whether Hamas was prepared to engage in new negotiations, but urged the group to do so.
