Chief Medical Officer Dr Tony Holohan will be stepping down from his role in the Department of Health.
Dr Holohan, who led the country through the Covid-19 pandemic, will be taking up a new position as Professor of Public Health Strategy and Leadership at Trinity College.
Taoiseach Micheal Martin lead tributes to Dr Holohan for his "outstanding service".
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Mr Martin said: "I would like to sincerely thank Chief Medical Officer Dr. Tony Holohan today as he prepares to step down after more than two decades of outstanding and dedicated service to the people of Ireland in the field of public health.
"His steadfast assured advice, and willingness to communicate over the course of the COVID-19 pandemic undoubtedly helped saved lives, and kept Ireland safe during an exceptionally challenging two years."
He added: "I have known Tony, and had the privilege to work with him, since he was appointed Deputy Chief Medical Officer in 2001, and then during his 14 years as the Chief Medical Officer.
"His work chairing the NPHET, his professionalism, and calm and personable nature gave us all the assurance we needed during the pandemic.
"In parallel, Tony worked consistently to raise and transform the profile and status of public health medicine, and worked hard on creating a professional pathway to consultant status.
"I wish him and his family the very best of luck for the future, and I look forward to engaging with Tony again when he takes up his position as Professor of Public Health Strategy and Leadership at Trinity College Dublin."
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