Mandatory Covid jabs for NHS and care staff will be axed within weeks, Sajid Javid has confirmed.
The Health Secretary said rules making the vaccine a "condition of deployment" for health workers would be revoked on March 15.
And the legal requirement will be scrapped on April 1.
In a written statement, Mr Javid said: "I have concluded that it is right and proportionate to proceed with revocation of Covid-19 vaccination as a condition of deployment in all health and social care settings, and have today published the government’s full response to the consultation on GOV.UK.
"I am also laying the regulations to revoke vaccination as a condition of deployment today.
"These regulations will come into force on 15 March, and will remove the requirements already in place in care homes, as well as those due to come into force in health and wider social care settings on 1 April 2022."
The U-turn was first announced in January after fears over the severity of the Omicron variant began to recede.
Mr Javid said: "My statement before the House [of Commons] on 31 January made clear that vaccination as a condition of deployment was the right policy when the original decision was taken, but that it is no longer proportionate in the light of the most recent clinical evidence regarding the current Omicron variant of COVID-19, which is intrinsically less severe than Delta, and the high rate of vaccination across the population."
A consultation was launched in early February on the issue - and 90% of respondents backed scrapping the legal requirement for health and social care staff to be double jabbed, the Government said.
But Mr Javid made it clear that it was "a professional responsibility for health and care staff, and others who work in the health and social care sectors, to be vaccinated" - despite removing the legal requirement.
Some 92% of the NHS workforce and 95% of care home staff are now double vaccinated, while 89% of home (domiciliary) care staff have so far received at least one dose.