Last season Helio Castroneves joined an exclusive club of four-time winners, and now sits alongside the likes of AJ Foyt, Rick Mears and Al Unser as the most successful drivers to compete at the Brickyard.
Many will be trying to stop him from claiming win number five this year, including reigning IndyCar champion Alex Palou and Chip Ganassi Racing team-mate Scott Dixon.
Looking ahead to qualifying this weekend and the race itself in 10 days is two-time Indy 500 winner and former Formula 1 driver Takuma Sato, who gives his thoughts on the drivers and teams in with a shot of victory.
Joining him for the latest Autosport Podcast is Motorsport.com's Charles Bradley and David Malsher-Lopez, with Martyn Lee as your host.
You can listen to the podcast using the player below, or via all good audio platforms including Spotify, Apple Podcasts and Google Podcasts.
