The slip road off the Erskine Bridge onto the northbound stretch of the A82 will be closed this weekend.
Essential maintenance is being carried out between Friday, March 4 until Monday, March, 7, which will see the off-slip shut for the entire time.
Work will be carried out continuously from 10pm on Friday evening with the route re-opening to public at 6am on Monday morning.
Traffic will be diverted onto the A82 southbound and where they will be able to join the northbound route at Mountblow overbridge.
However, this diversion is not suitable for HGVs, with drivers having to use Kilbowie roundabout to turn around.
The works involve repairs to the bridge deck, re-waterproofing and resurfacing.
Amey say the it will benefit road users by improving the condition of the carriageway and reducing the need for more extensive maintenance of the structure in the future.