Get all your news in one place.
100’s of premium titles.
One app.
Start reading
Benzinga
Benzinga
Technology
Vandana Singh

Why Alpine Immune's Shares Are Falling Today

Alpine Merck FDA MRK NYSE
  • The FDA has placed a partial clinical hold on Alpine Immune Sciences Inc's (NASDAQ:ALPN) NEON-2 trial evaluating davoceticept (ALPN-202) in combination with pembrolizumab in adults with advanced malignancies.
  • The partial clinical hold was prompted by Alpine's report of patient death in the NEON-2 trial. 
  • The participant had choroidal melanoma previously treated with nivolumab and ipilimumab and had received a single dose each of davoceticept and pembrolizumab. 
  • The treating physicians considered the participant's death to be attributed to cardiogenic shock as likely related to immune-mediated myocarditis or possibly infection.
  • In June, Alpine announced a clinical trial collaboration and supply agreement with Merck & Co Inc (NYSE:MRK) to evaluate ALPN-202 in combination with Merck's Keytruda (pembrolizumab).
  • Patients enrolled in the NEON-2 trial may continue to receive davoceticept and pembrolizumab, although no additional patients may be enrolled until the partial clinical hold is resolved. 
  • The partial clinical hold does not affect the ongoing NEON-1 clinical trial of davoceticept as monotherapy.
  • Price Action: ALPN shares are down 13.20% at $6.65 during the market session on the last check Monday.
Sign up to read this article
Read news from 100’s of titles, curated specifically for you.
Already a member? Sign in here
Related Stories
Top stories on inkl right now
One subscription that gives you access to news from hundreds of sites
Already a member? Sign in here
Our Picks
3 ways Trump is acting like a king and bypassing the Constitution’s checks and balances on presidential authority
I learned basic civics in my public school. But mostly, because it was more interesting, I also learned civics after school watching the animated series “Schoolhouse Rock,” often with my abuela – my grandmother – who took care of me.
The Conversation
The Conversation
Why the Internet Celebrated a Killer
Combine moral zealotry with increasingly blurred lines between political speech and violence long enough, and the outcome is predictable.
Reason
Reason
Worried About Premature Aging? Expert Recommends To Avoid 3 Food Items
An expert reveals three food items that could make people look older than they actually are.
Medical Daily
Medical Daily
We know so little about taking weight-loss drugs without prescription – is it really worth it?
Studies show that they’re effective for overweight people, but if you’re healthy, there are less risky ways to lose weight, says Devi Sridhar of Edinburgh University
The Guardian - UK
The Guardian - UK
NYC McDonald's Bans Customers Under Age 20 Amid In-store Violence: 'No Parent and ID, No Entry'
A New York McDonald's is banning the entrance of customers under 20 without adult supervision. The move follows a series of violent crimes at the Flatbush location as well as other local McDonald's.
International Business Times UK
International Business Times UK
Kanye West and Bianca Censori 'not giving up' on their marriage
A rep for Kanye West recently denied claims he had split from Bianca Censori, and a new report has claimed they have "decided to make their marriage work again".
BANG Premier
BANG Premier
Fourteen days free
Download the app
One app. One membership.
100+ trusted global sources.
Download on the AppStore Get it on Google Play