There has already been one giant-killing at the fourth-round stage of the FA Cup following Manchester United's exit at the hands of Middlesbrough.
Kidderminster Harriers and Plymouth Argyle both then came close to knocking out Premier League opponents only to be cruelly defeated in extra-time.
Everton made light work of their home tie against Brentford, meanwhile, as Frank Lampard guided the Blues to a 4-1 victory in his first match as manager.
Cardiff City are the side standing in Liverpool's way of a place in the fifth round of the competition, with the teams set to meet at Anfield on Sunday afternoon.
Klopp's side have won each of their previous four meetings between the sides.
When is the draw?
Ties for the fifth round will be drawn live on ITV at approximately 11:40am, 20 minutes prior to kick-off in the clash between Liverpool and Cardiff at Anfield.
It will also be streamed live on the official FA Facebook and Twitter pages.
What are the ball numbers for the draw?
1. Crystal Palace
2. AFC Bournemouth or Boreham Wood
3. Huddersfield Town
4. Peterborough United
5. Luton Town
6. Southampton
7. Chelsea
8. Everton
9. West Ham United
10. Middlesbrough
11. Tottenham Hotspur
12. Liverpool or Cardiff City
13. Stoke City
14. Nottingham Forest or Leicester City
15. Manchester City
16. Norwich City
When will fifth round ties be played?
Fifth-round ties will be played on the week commencing February 28.
Winning clubs will collect a total of £180,000 from the competition prize fund.