Both England and Italy suffered defeats in their opening Six Nations game and both will be hoping for a win here to avoid finishing 5th and 6th respectively as they did in last year's tournament.
However, there is only one expected winner in the fixture in Rome on Sunday with England, as expected, overwhelming favourites against a side who haven't won a Six Nations game since 2015.
However, with England having lost four of their last six games in the championship and with Italy's bold performance against France, an upset could well be on the cards here.
We already know that Lewis Ludlam is injured and was replaced in the squad by Joe Launchbury, however he has now been released from the squad along with Raffi Quirke, Alfie Barbeary, Jonny Hill, Courtney Lawes, Tom Pearson, Mark Atkinson, Tommy Freeman, George Furbank, Orlando Bailey, Ollie Hassell-Collins, Louis Lynagh and Luke Northmore.
Manu Tuilagi's progress is being monitored ahead of a return to action but this is expected to be for England's next fixture vs Wales on February 26.
This means that England fans can expect a relatively unchanged team for the match that will kick off at 3pm at Rome's Stadio Olimpico.
When is England's team announcement?
England will announce their team for the match at 11:30am on Friday morning, with Italy due to announce their XV at 2pm.
What are the other teams announcements?
Wales, Scotland, France and Ireland named their teams on Thursday ahead of Saturday's games with Wales hosting Scotland and France playing Ireland.
