Wales and England are ready to do battle at Twickenham in their Six Nations encounter on Saturday, with both teams looking to build on their respective wins last time out.
The old rivals head into the clash after Scotland v France kicks off the round-three action.
Wales, who haven't won at Twickenham in the Six Nations for 10 years, go into the grudge match following their bounce-back 20-17 win against Scotland in Cardiff in round two, which somewhat redeemed their 29-7 thrashing at the hands of Ireland a week prior.
England, meanwhile, unravelled in round one and lost 20-17 to Scotland at Murrayfield, before recording a 33-0 win against Italy last weekend.
Both sides will be targeting a win to keep their respective Six Nations title aspirations on track, with bragging rights on the table too.
Here's what you need to know about England v Wales:
What time is England v Wales kick-off?
England host Wales on Saturday, February 26, at 4.45pm at Twickenham.
What TV channel is England v Wales on? What about live streaming?
Coverage of Wales' match against England is being broadcast live on ITV and S4C. Viewers will also be able to live stream coverage via the ITV Hub and S4C Clic.
Read more: England v Wales referee Mike Adamson, the 'horrendous' claim and complaint to World Rugby
Read more: England v Wales head-to-head ratings as Welsh have four better players
What's the England v Wales team news?
England have been dealt a late blow after Manu Tuilagi was ruled out of Saturday's fixture no sooner than he had been named in the team.
On Thursday, he suffered a strain to the same hamstring which was torn against South Africa in the autumn, resulting in his withdrawal from the starting XV which had been named by Eddie Jones just hours earlier.
No sooner had the head coach warned Wales that England's "gainline accumulator" was back to his rampaging best, adding that "we're planning for him to be at full tilt", than he was on his way home.
England announced their reshuffle little more than an hour before kick-off, with Henry Slade shifting to 12 to start alongside Elliot Daly at 13 with Joe Marchant on the bench.
Elsewhere, Courtney Lawes is making his maiden England appearance of 2022 having overcome concussion, enabling him to pack down at blindside flanker and relieve Tom Curry of the captaincy duties.
In an unexpected twist, however, Ben Youngs must surpass Jason Leonard's record as England's most-capped male player as a replacement due to Harry Randall continuing as starting scrum-half. Youngs was expected to be restored at nine after being demoted for the five-try rout of Italy in Rome, but he will win his 115th cap off the bench before a full house at Twickenham.
Luke Cowan-Dickie displaces Jamie George at hooker, Maro Itoje moves from the back to the second row and Alex Dombrandt holds off the challenge of Sam Simmonds at number eight. Tighthead prop Kyle Sinckler will win his 50th cap.
As for the visitors, Wales boss Wayne Pivac has left out wing Louis Rees-Zammit and recalled Josh Adams and No. 8 Taulupe Faletau for Saturday's Six Nations clash against England.
Alex Cuthbert retains his place on the other wing and is set to win his 50th cap just days after becoming a dad for the second time.
Faletau makes his first Wales appearance for 11 months, having proved his fitness following a long-term ankle injury by playing in Bath's last two Gallagher Premiership matches against Wasps and Leicester. He last played for Wales in last year's Six Nations finale against France.
He lines up in the back-row alongside Ross Moriarty, who has switched to blindside flanker, and Taine Basham, who lines up at openside. Jac Morgan, who made his Test debut against Scotland 12 days ago, is on the bench.
Pivac has retained Owen Watkin and Nick Tompkins as his centre combination, while there are call-ups among the replacements for Ospreys fly-half Gareth Anscombe, Scarlets scrum-half Kieran Hardy and Dragons prop Leon Brown.
England: 15. Freddie Steward, 14. Max Malins, 13. Elliot Daly, 12. Henry Slade, 11. Jack Nowell, 10. Marcus Smith, 9. Harry Randall, 1. Ellis Genge, 2. Luke Cowan-Dickie, 3. Kyle Sinckler, 4. Charlie Ewels, 5. Maro Itoje, 6. Courtney Lawes (capt), 7. Tom Curry, 8. Alex Dombrandt.
Replacements: 16. Jamie George, 17. Joe Marler, 18. Will Stuart, 19. Nick Isiekwe, 20. Sam Simmonds, 21. Ben Youngs, 22. George Ford, 23. Joe Marchant.
Wales: 15. Liam Williams, 14. Alex Cuthbert, 13. Owen Watkin, 12. Nick Tompkins, 11. Josh Adams, 10. Dan Biggar (capt), 9. Tomos Williams, 1. Wyn Jones, 2. Ryan Elias, 3. Tomas Francis, 4. Will Rowlands, 5. Adam Beard, 6. Ross Moriarty, 7. Taine Basham, 8. Taulupe Faletau.
Replacements: 16. Dewi Lake, 17. Gareth Thomas, 18. Leon Brown, 19. Seb Davies, 20. Jac Morgan, 21. Kieran Hardy, 22. Gareth Anscombe, 23. Jonathan Davies.
What's your England v Wales prediction?
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Why isn't Louis Rees-Zammit playing for Wales?
Pivac said experience and work-rate off the ball went in favour of Louis Rees-Zammit's wing rivals Josh Adams and Alex Cuthbert for this match.
Rees-Zammit will instead feature among the replacements for Gloucester when they face Leicester in the Gallagher Premiership on Saturday as players with English clubs are released back to them if they are not involved in a Wales matchday 23.
He is one of the most exciting players in European rugby, collecting four tries during last season's Six Nations and being picked for the British and Irish Lions' South Africa tour.
The 21-year-old has carved out a reputation for scoring dazzling solo tries, which he underlined with a breathtaking touchdown against Fiji during this season's Autumn Nations Series, but has been axed for England v Wales.
Explaining the decision, Pivac said: "Everybody wants to be selected and is working pretty hard. For us, with this particular match, looking at the opposition and the way we think the game will be played, I think the experience of the other two, work-rate off the ball and those sorts of things, are really going to come into play. It’s a tough call on Louis but one that we think is the right call.
"He’s disappointed, obviously. He’ll be frustrated but I think if you look back to the first Six Nations, he didn’t get any game time, he went away, listened to what the coaches had passed on, work hard and then had a very successful Six Nations last year. We expect him to go and work hard on his game and come back stronger than he is.
"There are a few things that we’ve spoken to him about and also George Skivington, his Gloucester coach. He knows what it is."
Cuthbert shone against Scotland, while Adams, who missed that game due to a calf muscle problem, has repeatedly excelled for Wales, with 17 tries in 36 Tests.
Pivac added: "I am really pleased for Alex Cuthbert to get 50 Tests for his country. It is a massive achievement.
"And it is also great to have Josh Adams back from injury. They are two good players. That means Louis Rees-Zammit is the unfortunate one this week that misses out.
"But we have looked at the opposition we're playing and niggly injuries that players pick up from time to time, and we think that in this particular match, the way the game will go, that Alex and Josh are the right selection."
Why isn't Manu Tuilagi playing for England and when will he be fit again?
Sale centre Tuilagi has not been ruled out of the final two Six Nations rounds against Ireland and France pending an update on the severity of his hamstring strain, but given his long injury history, his prospects of being involved in this Six Nations look bleak.
"Manu had a slight hamstring strain at training on Thursday, so he's left camp and is at home," forwards coach Richard Cockerill said.
"It's not too serious as far as we know and hopefully he'll be back soon. Manu is in pretty good spirits. Unfortunately this is part of professional sport.
"Manu's still got a smile on his face and is optimistic that he'll be back playing for club and country pretty soon."
Apart from the crushing sense of misfortune that Tuilagi must endure yet again, England are having to revise their strategy to take on the champions at Twickenham.
Tuilagi's powerful ball carrying brings balance to a midfield that includes Marcus Smith and Henry Slade and his absence robs the team of their ability to be direct in attack.
"We've got options at outside centre. Joe [Marchant] has played there a fair bit and there are other options with Elliot Daly," Cockerill said.
"That will be decided over the next 24 hours and it will be announced as we arrive at the stadium."
What have the coaches said?
England head coach Eddie Jones: "It is a hard fought goes-to-the wire type of game and as a coach those are the games you like to be involved in. You just don’t want them to go too close to the wire.
"If you go into the last two games with a 2-1 record, you are going to be in with a chance of winning the trophy. So both teams understand what is at stake and both will be well prepared. It’s going to be a tough old game.
"Wales are a tough side to beat. They are always in the contest and they always keep coming at you. One of the important things for us is that we go at them early and don’t let them settle into that grind. They love the grind of international rugby.
"It will be a big test – Wales always are. They’ve got a great tradition in their rugby in Wales of being tough, staying in games and finding a way to win possession, through their high balls or attacking the breakdown. They find a way to stay in the game and we’re prepared for that. We know it’s coming and it will be a leadership test."
Wales head coach Wayne Pivac: "We need to transfer the performance we had in front of our own supporters away at Twickenham. That’s the big challenge in front of us. Playing in front of a full house, whether it’s home or away, is an exciting prospect.
"We know it means a lot to the public and we know it means a lot to the players. It’s a big match that everyone looks forward to each year.
"The big challenge for us is to have that same attitude and the same willingness to throw ourselves around the park like we did last week [against Scotland] in front of 70,000-odd mainly Wales fans, to do that on the road in a hostile environment with mainly English supporters.
"That’s one of the big challenges we’ve talked about during the week, is being able to compete with the English pack, which is a big pack, and making sure we’re disciplined and don’t give them too many inroads with their lineout and obviously they’ve got a pretty good scrum. It’s a big challenge for us up front and we need to back that up across the whole 15."
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