England host Ireland in round four of the Six Nations in what is set to be a pivotal game in deciding the outcome of the 2022 Championship.
Eddie Jones has said his side have been treating the fourth-round clash as "a semi-final", knowing that defeat for either team would effectively end their respective title hopes.
Ahead of Saturday's game, Jones has talked up the visitors and billed them as "red-hot favourites", despite Andy Farrell's side having lost on their last three visits to Twickenham.
Both coaches have named strong starting XVs, with Sam Simmonds replacing Alex Dombrandt at No. 8 for the hosts, while Ireland skipper Jonny Sexton - who this week announced he would retire after the 2023 World Cup - returns to lead out his side.
Here's everything you need to know about Saturday's match:
What time is England v Ireland kick-off?
England v Ireland kicks off at 4.45pm on Saturday, March 12, at Twickenham Stadium.
What TV channel is England v Ireland on? What about live streaming?
England v Ireland is being broadcast live on ITV1 with coverage starting at 4.15pm.
You will also be able to watch the match via live stream using the ITV Hub.
What's the England v Ireland team news?
Sam Simmonds starts at number eight for England in one of two changes made by Eddie Jones to the side which beat Wales a fortnight ago. He replaces Alex Dombrandt, who has sufficiently recovered from coronavirus to secure a place on the bench for the pivotal clash with Ireland, following a successful run-out in training midweek.
The second change sees Joe Marchant preferred ahead of Elliot Daly at outside centre, with the Harlequins man partnering Henry Slade in midfield.
England have also been lifted by the presence of Tom Curry, who has passed the return-to-play protocols form concussion to continue at openside, while Courtney Lawes will again captain the side after leading them to victory against Wales.
Joe Launchbury is poised to make his first England appearance since December 2020 after completing his recovery from a serious knee injury if he comes off the bench.
As for the visitors, Ireland skipper Johnny Sexton returns to the starting line-up as Andy Farrell makes six changes ahead of the fourth round.
Bundee Aki starts at inside centre, replacing Robbie Henshaw who moves to the bench, but there is no place in the squad for the in-form Mack Hansen as James Lowe is restored on the left wing.
Despite scoring two tries on his debut against Italy a fortnight ago, Ulster's Michael Lowry has also been dropped from the matchday squad, with Hugo Keenan reclaiming the No. 15 jersey.
Loosehead prop Andrew Porter will miss the rest of the Six Nations after picking up an ankle injury, but he is replaced by the hugely experienced Cian Healy, who will win his 115th cap.
Healy completes an all-Leinster front row alongside Dan Sheehan and Tadhg Furlong, while James Ryan returns to start at lock alongside Munster's Tadhg Beirne.
England: 15. Freddie Steward; 14. Max Malins, 13. Joe Marchant, 12. Henry Slade, 11. Jack Nowell; 10. Marcus Smith, 9. Harry Randall; 1. Ellis Genge, 2. Jamie George, 3. Kyle Sinckler, 4. Maro Itoje, 5. Charlie Ewels, 6. Courtney Lawes (capt), 7. Tom Curry, 8. Sam Simmonds.
Replacements: 16. Jamie Blamire, 17. Joe Marler, 18. Will Stuart, 19. Joe Launchbury, 20. Alex Dombrandt, 21. Ben Youngs, 22. George Ford, 23. Elliot Daly.
Ireland: 15. Hugo Keenan; 14. Andrew Conway, 13. Garry Ringrose, 12. Bundee Aki, 11. James Lowe; 10. Jonny Sexton (capt), 9. Jamison Gibson-Park; 1. Cian Healy, 2. Dan Sheehan, 3. Tadhg Furlong, 4. Tadhg Beirne, 5. James Ryan, 6. Peter O'Mahony, 7. Josh van der Flier, 8. Caelan Doris.
Replacements: 16. Rob Herring, 17. Dave Kilcoyne, 18. Finaly Bealham, 19. Iain Henderson, 20. Jack Conan, 21. Conor Murray, 22. Joey Carbery, 23. Robbie Henshaw.
Who is the England v Ireland referee?
Referee: Mathieu Raynal (FFR)
Assistant referees: Mike Adamson (SRU) and Pierre Brousset (FFR)
TMO: Marius Jonker (SARU)
What have the coaches said?
England head coach Eddie Jones: "Ireland haven't played against a team like us before - they haven't played against South Africa since 2017. We played against South Africa last year and did well in those physical stakes, so we intend to really take it to them.
"We play with a physicality they haven't seen before. We have one intention in this game and that's to go after Ireland. We are going to chase them hard down the street. Everywhere they go, we're going to be in their faces and we're going to take time and space away from them. Do we enjoy that challenge? Yes. This team don't know how good they can be and we are certainly going to find out on Saturday how good we can be."
On Andy Farrell's team selection, he said: "We're more concerned about ourselves. What I do know is they're red hot favourites.
"I went to the coffee shop on Wednesday and the girl says 'that Irish team must be good, all their ex-players think they're going to win the game and all the ex-England players think they're going to win the game. They must be a pretty good team. How you feeling?'
"I said 'just give me the coffee please'.
"It's a semi-final. One of the two teams progresses to the final, which is the last game. Both teams know what's at stake. But if you read the papers, there is only one team that has a chance of winning it.
"When you're playing against a team that has to basically jump out of the barrier and win, then you've got to make sure your horse is ready to go. All I've been doing is trying to get my horse ready to go."
Ireland head coach Andy Farrell: "We respect every team that we play. But we certainly respect the challenge ahead of us this weekend going to Twickenham.
"Listening to Joe Marler's comments during the week - regarding he's never thought of being anything but a favourite at Twickenham, and rightly so - their record is very good there. It's a massive challenge for us this weekend and something we're looking forward to."
On Jones' comments about Ireland being favourites, Farrell said: "It doesn't bother me whatsoever. I don't see what it does for and against, it's just about us preparing properly.
"I also know that Eddie has said plenty of times in the past as well that 'praise makes you weak'. We make sure that we just take care of our own house and prepare properly over the next coming days and be ready to perform."
On his selection calls, he added: “We just think the balance is right for this game. Pete [O’Mahony] is in good form. Not just physically, but he’s a good emotional leader for us as well.
“Leadership is a big part of every team performance. Obviously we know what Pete brings as far as the set-piece is concerned and the breakdown is concerned, but the rest of his game has come on an absolute treat.
“His attack stuff has really stepped up. I think he played really well against Italy. I also thought Jack [Conan] played really well coming off the bench and had a big impact. Again, I think the balance is right for this week."
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