Since taking over as Kansas City Chiefs starting quarterback, Patrick Mahomes has lost to the same team twice in one season twice.
The first time happened in 2018 when the Chiefs fell to the New England Patriots 43-40 in the regular season and 37-31 in the AFC Championship Game.
The Cincinnati Bengals are the only other team to down Mahomes’ Chiefs twice in a season. That occurred in the 2021 season when the Cincinnati Bengals downed the Chiefs, 34-31, in the regular season, and 27-24 in the AFC Championship Game.
Both of the second losses took place in overtime games.
The Bills look to beocme the third team to defeat Mahomes’ Chiefs twice in one season on Sunday when the teams meet in the AFC Championship Game at Arrowhead Stadium.