It's the first in a triple header that will go a long way to defining how Celtic and Rangers view their seasons.
They have already locked horns on three occasions this term with the Hoops most recently winning the League Cup Final in February.
But now they meet in their third Premiership clash of the season, with Ange Postecoglou's leaders out in front by nine points.
Read next: Dundela FC 'devastated' by sad passing of Aodhán Gillen
Michael Beale's chasers need a win to keep their title hopes alive and anything but at Parkhead will all but end their chances for another year.
It's also set to be a unique occasion in that there will be no fans in the Rangers corner willing the Ibrox club on to victory.
Instead it will be sold-out cauldron of green and white noise eager to see Celtic take one step closer to another trophy under their Australian leader.
Here's everything you need to know about the latest derby drama.
When and where will the game take place?
The game takes place at Parkhead on Saturday, April 8. Kick off is at 12.30pm.
What channel is it on?
The clash has been moved to the earlier kick-off slot as it will be shown live on Sky Sports. You can watch it on Sky Sports Football. You can subscribe to Sky Sports here from £18 per month. Highlights will also be shown on BBC Sportscene which starts at 7.15pm on Sunday night.
Will there be a live stream?
Yes, Sky Sports customers can stream the game live to their devices via the Sky Go app. Alternatively it can be streamed on Now TV with a Day Pass available at NowTV.com for £11.99.
READ NEXT:
- Tony Mowbray says Northern Ireland's right-back must be 'some player' to play ahead of Trai Hume
- Rory McIlroy lifts lid on injury 'wake up call' that changed his life and career
- Unbelievable comeback for Declan Caddell as another fairytale ending is in sight
- Conor Glass injury a real concern admits Derry boss Rory Gallagher
Sign up to our free sports newsletter to get the latest headlines to your inbox.
