Following their opening day statement victory over England, Gregor Townsend and his Scotland side will be wanting to maintain their 100% record in the Six Nations when they travel to Cardiff this weekend.
The Scots secured successive Calcutta Cup victories for the first time since 1984, after a dramatic late penalty try helped them claim a nail-biting victory over England.
Gregor Townsend has made five changes from his side's impressive Calcutta Cup victory over England at Murrayfield last weekend and has picked an entirely new front row for the game at the Millenium Stadium.
Scotland head to Cardiff with Pierre Schoeman, Stuart McInally and WP Nel all coming in while Sam Skinner of Exeter replaces the injured Jamie Ritchie.
Last week's front row looks to have been rested as Rory Sutherland, George Turner and Zander Fagerson all take their places on the bench looking to make an impact in the second-half.
Sione Tuipulotu gets the nod instead of Sam Johnson in the centres while Cameron Redpath could add to his solitary cap from the bench, after helping Scotland to a win over England at Twickenham last February.
For Wales meanwhile, changes were necessary after a disappointing start to the competition resulted in heavy defeat to Ireland in Dublin.
Jac Morgan receives his test debut in the back-row while Ross Moriarty also comes in at Number-8 as Ellis Jenkins and Aaron Wainwright miss out.
Josh Adams, who endured a difficult time in Dublin has a calf injury and is replaced by Owen Watkin in the centres and Alex Cuthbert makes his first Six Nations appearance in five years, replacing Jonny McNicoll.
Captain Dan Biggar will make his 100th test appearance, which includes three for the British and Irish Lions while Jonathan Davies could join him on that milestone if he comes off the bench.
Wales know that a first Scotland victory in Cardiff since 2002 this Saturday would effectively end all hope of a successful Six Nations title defence.
The last time these two sides met, Wales edged out Scotland at Murrayfield 25-24, following pieces of individual brilliance from Ress-Zammit after Zander Fagerson's sending off.
Ahead of this eagerly anticipated match in Cardiff, here is everything you need to know:
What time is kick-off?
The match takes place on Saturday 12 February, kicking off at 2:15pm.
Where can I watch the match?
You can watch the match on BBC One, with the game also streamed via BBC iPlayer.
What is the team news?
Wales: L Williams; Cuthbert, Watkin, Tompkins, Rees-Zammit; Biggar (capt), T Williams; W Jones, Elias, Francis, Rowlands, Beard, Basham, Morgan, Moriarty.
Replacements: Lake, G Thomas, D Lewis, S Davies, Wainwright, G Davies, Sheedy, J Davies.
Scotland: Hogg (c); Graham, Harris, Tuipulotu, Van der Merwe; Russell, Price; Schoeman, McInally, Nel, Gray, Gilchrist, Skinner, Watson, M Fagerson.
Replacements: Turner, Sutherland, Z Fagerson, Bradbury, Darge, White, Kinghorn, Redpath
