Tottenham Hotspur boss Antonio Conte has confirmed that Rodrigo Bentancur is unavailable for his side's trip to Leeds United on Saturday afternoon.
The Uruguay international has started Spurs' last three Premier League matches since signing from Juventus in January, but will miss the game after suffering an ankle injury in the 1-0 defeat at Burnley.
With Oliver Skipp also out, Conte has a midfield selection dilemma given Bentancur's form and his influence on the 3-2 win over Manchester City last weekend.
Pierre-Emile-Hojberg and Harry Winks are now expected to be the midfield-two in their absence, while Japhet Tanganga remains out but Conte is hopeful that the defender can return soon.
Speaking in his pre-match press conference, Conte said: "Unfortunately he's (Bentancur) not available for tomorrow's game. He had a problem in his ankle.
"I don't think this is a serious problem. I hope to see him in the team very soon but for sure he's not available tomorrow.
"No this is another problem. I hope the medical department help me.
"Skipp is now one month missing. Same with Tanganga. I don't want to put pressure on the medical department but for sure I need help with the situation."
Like Bentancur, Kulusevski is another player who has impressed following his six-month switch from the Italian giants last month, scoring his first Spurs goal last weekend.
However, the Swedish midfielder finished the game at Burnley as a wing-back despite being a more natural forward.
Conte has revealed that he could stick with Kulusevski in that role, while he explained that Steven Bergwijn has also done well in a deeper position and could start this weekend.
He added: "We finished the game with Kulusevski and Bergwijn as wing-backs. We finished with an offensive formation.
"Steven Bergwijn is a number 10, a forward, but he was playing there.
"Kulusevski is another player that can play in that role and give us the quality. This can be also a good solution in this position.
"I think he's playing good games and he's totally involved in our idea, with Bentancur, and I'm very happy with what I'm seeing with these two players."
