An Israeli "aggression" launched from the Golan Heights and targeting southern parts of the Syrian capital Damascus killed three people and caused some material damage, the Syrian ministry of defence said on Friday.
Earlier on Friday, state TV reported that Syrian air defences shot down a number of missiles in the Damascus countryside.
The Israeli military declined to comment.
For several years, Israel has been mounting attacks on what it has described as Iranian-linked targets in Syria, where Tehran-backed forces, including Lebanon's Hezbollah, have put down a presence since deploying to help President Bashar al-Assad in the Syrian civil war which broke out in 2011.
(Reporting by Enas Alashray, Lilian Wagdy and Kinda Makieh; Editing by Grant McCool)