The incidence rate of Covid-19 has surged in a number of counties as NPHET prepare for a major meeting on Thursday.
The group is set to meet on Thursday afternoon to advise the Government about the latest public health data.
It is expected that Ireland will lift more Covid-19 restrictions over the next few weeks.
But there are still some areas of concern - with one county even having an incidence rate of nearly five times the national rate of 1887.8 cases per 100,000 people.
Westmeath is well above the rest of the country at time of writing.
In the previous seven days up to Monday, their incidence rate was a huge 5,154.9 cases per 100,000 population.
That was after 4,576 new cases in the week leading up to Monday, per the latest HPSC data.
Just two weeks ago, Westmeath's rate stood at 3,051.7.
Clare is second in the table, with a rate of 3,308.4 cases per 100,000 people.
That's also a worrying rise since this time a fortnight ago, with 3,931 new cases recorded last week.
Longford (3014.2), Carlow (2,778.8) and Galway (2738.1) round out the top five regions worst-hit by Covid.
Meanwhile, rates fell in the likes of Cavan, Donegal, Dublin and Kilkenny.
However, Waterford is the standard-bearer at the moment, with a rate of just 1175.8 cases per 100,000 people.
At times in 2021, the Munster region was struggling to control the virus, a far cry from the current day.
Taoiseach Micheal Martin has confirmed that Cabinet will meet again on Friday to give clarity to the public and to businesses, after which he is expected to make an announcement.
Before that, NPHET will make their recommendations to Minister for Health Stephen Donnelly in a letter, expected to be delivered on Thursday evening.
