The executive chairman of Star Entertainment Group, John O'Neill, has tendered his resignation and will step down from the board.
That announcement was made to the Australian Stock Exchange (ASX) with a departure date yet to be set.
"Mr O'Neill informed fellow directors late today of his decision," the company's statement said.
"Mr O'Neill will transition his chair and executive responsibilities in an orderly manner."
The resignation comes as an inquiry by the Independent Liquor and Gaming Authority continues into The Star's suitability to run its Sydney casino.
The public inquiry being conducted by Adam Bell SC has heard evidence of a secret junket room operating at the casino, senior managers turning a blind eye to money laundering risks and misleading the Independent Liquor and Gaming Authority and the National Australia Bank.
In late March, Star Entertainment Group's managing director and chief executive, Matt Bekier, tendered his resignation.
Mr O'Neill was appointed to the role in April on an Interim basis after Mr Bekier's exit.
"Interim arrangements will be announced once finalised. A search for a permanent [chief executive] was commenced last month," the company's statement said.
Other resignations include chief financial officer Harry Theodore, chief casino officer (NSW) Greg Hawkins and chief legal & risk officer and company secretary Paula Martin.
Mr O'Neill has held other high-profile roles including CEO of Australian Rugby Union and Football Federation Australia.
He was scheduled to give evidence at the inquiry next week.