The Taoiseach has said that the Government is expecting to lift restrictions from the start of next week.
NPHET will meet on Thursday afternoon to analyse the latest data surrounding Covid-19 and make their recommendations to Government.
It is expected that the group, led by Chief Medical Officer Dr Tony Holohan, will give the green light to the Government to re-open the country further.
This will likely include the end of the 8pm curfew on hospitality, the return of crowds to indoor and outdoor events (including sports) and a future plan for the rest of the spring and early summer.
Speaking to Morning Ireland on RTE on Thursday, Taoiseach Micheal Martin said: "The Government will meet tomorrow [Friday], after that I intend to give a clear statement about what lies ahead in the short term and medium term.
"The public health perspective is now that there has to be a rationale for measures.
"The situation is positive. The combination of the booster campaign and the fact that Omicron isn't as virulent as Delta and other waves has meant the impact on people has been much less. We can be positive.
"I thank the people of Ireland for how they have adapted so that we were able to control Omicron. I think we are entering a new phase. We intend now to live with Covid over the next while, because it isn't going away.
"It's very possible change will happen next week. The original restrictions were in until January 31 but we are hoping to have an earlier lifting of restrictions."
However, the Taoiseach noted that some rules will remain.
He said: "There are some areas we want to keep - there could be another chapter in Covid yet and we need to be mindful that the pandemic is not over. Mask wearing will be an important feature. [What we're seeing in the UK] is a long way away yet. "
Mr Martin also repeated his plea to the public to get their vaccinations when possible.
He said: "The booster campaign will now likely go out to April as a lot of people haven't been in a position to get a booster.
"The booster has been the best weapon against Omicron. It's the un-boosted and unvaccinated who are suffering the most in hospitals.
"Who would have said 12 months ago we'd be tolerating 20,000 cases a day and not be in Level 5? The fact we aren't there is down to the vaccines."
