The Syrian Observatory for Human Rights revealed that the Israeli strike on Aleppo on Wednesday destroyed a weapons cache used by Iranian militias in the vicinity of Aleppo International Airport.
A top Syrian commander was among four killed in the attack.
One of the dead was another Syrian, while the other two have not been identified.
The attack had taken the airport out of service. It will resume operations on Friday.
This is the second time Israel strikes the airport within a month.
The airport has been a key channel for the flow of aid into the country after the Feb. 6 earthquake hit Türkiye and Syria, killing over 50,000 people, including more than 6,000 in Syria.
Earlier this month, an Israeli airstrike put the airport out of service for several days and flights were rerouted to two other airports in war-torn Syria until the damage was fixed.
Israel has carried out hundreds of strikes on targets inside government-controlled parts of Syria in recent years, including attacks on the Damascus and Aleppo airports, but rarely acknowledges or discusses the operations.
Israel has acknowledged, however, that it targets bases of Iran-allied militant groups, such as Lebanon’s Hezbollah, which has sent thousands of fighters to support Syrian President Bashar Assad’s forces.
Along with airports, Israel has also targeted seaports in government-held areas, an apparent attempt to prevent Iranian arms shipments to militant groups backed by Tehran, including Hezbollah.
Late on Wednesday, the Israeli military said a drone crashed in Syria while on a “routine operation.” It said no sensitive information had been lost and it was investigating the incident.