Bath Rugby centre Ollie Lawrence will miss England's final game of the 2023 Guinness Six Nations against Ireland after limping off the pitch during Saturday's 53-10 defeat to France at Twickenham.
Lawrence was unavailable for selection after sustaining a hamstring injury in the heavy defeat but effectively has been replaced in head coach Steve Borthwick's latest 36-man squad by Sale Sharks' Manu Tuilagi, with Guy Porter also coming in from Leicester Tigers.
Tuilagi has been with the squad for the last couple of weeks but has been serving a ban for high contact with his elbow while carrying the ball. Lawrence has been one of the bright spots in a challenging championship for England but now faces a spell on the sidelines, creating further injury problems for bottom-of-the-table Bath.
There are also returns to the England squad for British and Irish Lions lock Jonny Hill and Harlequins tighthead prop Will Collier.
Having been battered by the number two ranked side in the world on Saturday, England will travel to Dublin to take on number one ranked Ireland at the Aviva Stadium on Saturday 18 March (5pm KO) in their final game of the championship.
Ireland v England is live on ITV and BBC Radio 5 Live.
FULL SQUAD
FORWARDS
Ollie Chessum (Leicester Tigers, 9 caps)
Dan Cole (Leicester Tigers, 99 caps)
Will Collier (Harlequins, 2 caps)
Ben Curry (Sale Sharks, 4 caps)
Alex Dombrandt (Harlequins, 13 caps)
Tom Dunn (Bath Rugby, 3 caps)
Ben Earl (Saracens, 15 caps)
Ellis Genge (Bristol Bears, 47 caps)
Jamie George (Saracens, 76 caps)
Jonny Hill (Sale Sharks, 19 caps)
Nick Isiekwe (Saracens, 10 caps)
Maro Itoje (Saracens, 66 caps)
Lewis Ludlam (Northampton Saints, 18 caps)
David Ribbans (Northampton Saints, 4 caps)
Bevan Rodd (Sale Sharks, 2 caps)
Kyle Sinckler (Bristol Bears, 60 caps)
Mako Vunipola (Saracens, 78 caps)
Jack Walker (Harlequins, 3 caps)
Jack Willis (Toulouse, 9 caps)
BACKS
Henry Arundell (London Irish, 6 caps)
Owen Farrell (Saracens, 105 caps)
Tommy Freeman (Northampton Saints, 3 caps)
George Ford (Sale Sharks, 81 caps)
Ollie Hassell-Collins (London Irish, 2 caps)
Max Malins (Saracens, 18 caps)
Joe Marchant (Harlequins, 14 caps)
Alex Mitchell (Northampton Saints, 4 caps)
Cadan Murley (Harlequins, uncapped)
Guy Porter (Leicester Tigers, 4 caps)
Henry Slade (Exeter Chiefs, 55 caps)
Marcus Smith (Harlequins, 21 caps)
Freddie Steward (Leicester Tigers, 21 caps)
Manu Tuilagi (Sale Sharks, 50 caps)
Jack van Poortvliet (Leicester Tigers, 11 caps)
Anthony Watson (Leicester Tigers, 54 caps)
Ben Youngs (Leicester Tigers, 122 caps)
