Newcastle United were dealt a double blow with both Allan Saint-Maximin and Joelinton missing with illness and a knock respectively at Southampton.
Although, Joelinton was part of the squad that is staying in the south and could yet feature against Chelsea on Sunday afternoon.
However, the omission of the former Hoffenheim man meant that Bruno Guimaraes was handed his long-awaited first start.
Otherwise, it was the team that picked up a 2-1 win over Brighton & Hove Albion with Eddie Howe sticking with Jacob Murphy as part of his attack.
Youngster Lucas De Bolle is on the bench while Miguel Almiron still awaits his 100th Premier League appearance for the club.
READ MORE: Eddie Howe's response when asked about Antonio Rudiger
Tonight's teams
Newcastle: Dubravka, Krafth, Burn, Schar, Targett, Bruno, Willock, Shelvey, Murphy, Wood, Fraser
Subs: Darlow, Manquillo, Lascelles, Dummett, Ritchie, S Longstaff, De Bolle, Almiron, Gayle.
Southampton: Forster, Livramento, Bednarek, Salisu, Walker-Peters, Romeu, Ward-Prowse, S Armstrong, Elyounoussi, Broja, Adams
Subs: Caballero, Stephens, Valery, Perraud, Diallo, Smallbone, Djenepo, Long, A Armstrong
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