Ivan Toney scored as Brentford recovered from Saturday’s defeat at Everton by beating Southampton.
Toney reacted first in the 32nd minute to score from a Bryan Mbeumo corner and take his league tally to 16 for the season.
Southampton dominated possession and racked up 563 passes, their highest total this season, but were unable to penetrate Brentford’s defence as they missed the chance to move out of the relegation zone.
Yoane Wissa then sealed their fate deep into stoppage time with a goal on the counter-attack.
Brentford, who suffered their first defeat in 12 Premier League games at the weekend, moved above Fulham into eighth place in the table with 41 points.
Southampton’s best chance came just after halftime when a flowing move down the right ended with a Che Adams close-range effort being blocked on the line by Aaron Hickey.
The south coast club remained on 22 points from 27 games, two adrift of 17th-placed West Ham United.
Gareth Southgate will select his England squad for the Euro 2024 qualifiers against Italy and Ukraine on Thursday.
Only Norway’s Erling Haaland and England captain Harry Kane have scored more Premier League goals than Toney this season.
Brentford host Leicester City at the weekend when Southampton entertain Tottenham Hotspur.
