The San Francisco 49ers stretched their winning streak to six games and clinched the NFC West with a 45-29 win over the Arizona Cardinals.
San Francisco quarterback Brock Purdy improved upon his MVP credentials with four touchdowns and 242 passing yards in another stellar addition to his breakout season.
Arizona put some pressure on early with a touchdown in the first two minutes, but the 49ers responded with back-to-back touchdowns of their own and never let up from there.
Fellow contenders the Dallas Cowboys were brought back to reality courtesy of a 31-10 demolition at the hands of the Buffalo Bills.
The 10-win Cowboys’ defence looked powerless against Buffalo’s running game, with James Cook, Josh Allen and Latavius Murray all finding the end zone on the ground.
Despite the loss, other results from earlier in the day ensured the Cowboys would be in the playoffs for the third-straight year.
The Cleveland Browns scored 13 fourth-quarter points to snatch a 20-17 victory over the Chicago Bears.
The two sides were level at 7-7 at the break after tight ends Cole Kmet and David Njoku scored touchdowns but the Bears took a 10-point lead into the fourth after Tremaine Edmunds returned an interception 45 yards for a touchdown.
But the Browns saved their best till last and two Dustin Hopkins field goals partnered an Amari Cooper touchdown to give them the win, with 38-year-old Joe Flacco throwing for 374 yards.
Super Bowl champions the Kansas City Chiefs returned to winning ways with a 27-17 victory over the New England Patriots.
Running back Jerick McKinnon caught one touchdown pass and threw another to Rashee Rice while Patrick Mahomes threw for 305 yards, two scores and two interceptions.
Baker Mayfield threw for four touchdowns as the Tampa Bay Buccaneers earned a 34-20 win over the in-form Green Bay Packers.
The 28-year-old quarterback racked up 381 passing yards over the game to four different scorers, David Moore, Mike Evans, Rachaad White and Ko Kieft, to help wrap up a convincing win.
Raheem Mostert rushed for two touchdowns as the Miami Dolphins crushed the New York Jets 30-0.
The 31-year-old opened the scoring in the first quarter but the damage was done in the second when he ran over for his double after Jaylen Waddle’s 60-yard score had already given the home side a healthy advantage and moved them up to second in the AFC.
The New Orleans Saints scored 17 second-half points to secure a 24-6 victory over the New York Giants.
Derek Carr threw for three touchdowns as the Saints took over in the second period without reply from the Giants.
Ka’imi Fairbairn kicked an overtime field goal to help the Houston Texans claim a 19-16 victory over the Tennessee Titans.
The Carolina Panthers scored two field goals in the final quarter to claim just their second win this campaign with a 9-7 win over the Atlanta Falcons.
Elsewhere, the Los Angeles Rams beat the Washington Commanders 28-20, the Detroit Lions cruised past the Denver Broncos 42-17 and the Baltimore Ravens eclipsed the Jacksonville Jaguars 23-7.
