Trent Robinson will watch the Sydney Roosters' clash with North Queensland from home after testing positive for COVID-19.
Robinson has confirmed he contracted the virus in recent days and would miss attending a Roosters match for the first time since taking the reins in 2013.
He becomes the second coach to miss a game with the virus this year, after his former assistant Craig Fitzgibbon tested positive before Cronulla's season opener.
Roosters players had been given a week off after their 28-16 loss to South Sydney, while all staff who enter the club's headquarters or training are tested daily.
"I'm feeling fine and am very comfortable with the plans we have in place, and I'll be back at the club next week," Robinson said in a statement.
Matt King, Brett Morris and Jason Ryles are the Roosters' three assistants and will take on more of a role on Saturday night.
Robinson's absence was confirmed after Roosters lock Victor Radley detailed how the coach had helped him mature in recent years.
Radley was involved in off-field trouble twice last season, with Robinson at one point publicly telling him it was time to grow up.
The 24-year-old has made a point to try and mature in the past nine months, while also putting a heavy emphasis on getting his tackle technique right to avoid more suspensions.
"He's had some honest conversations with me," Radley said.
"He's sat me down in his office and told me how it is. I'm lucky to have someone like that, that I really respect and can tell me how it is.
"Often mum can sugar-coat it or my dad might not really care that much.
"But to have someone like that sit me down and tell me how it is, it has really helped."
Radley has insisted in recent years he wants to become a leader in the Roosters group and admitted in the off-season he had let himself down in that regard.
He accepted that it could take up to two years to prove that with his current contract up at the end of next season.
"I took a backwards step (and looked at myself)," Radley said.
"I did love being the biggest dickhead in my group of friends. But I can't do it all the time.
"Some stuff happened in 2020, you can call it a light-bulb moment.
"I can't do anything without learning the hard way.
"I learned some really good lessons. I hope to say I have matured and moved forward.
"I'd like to think I am in a good spot right now to go and spend 12 or 24 months doing that and hopefully I can get a bit more respect from my peers and they can really respect me as a leader."