Madeleine McCann disappeared 16 years ago without a trace, but her parents, Kate and Gerry McCann, have never given up hope of finding her.
The McCann family, including twins Amelie and Sean, now 18, were on holiday in Praia da Luz, Portugal, when Maddie was last seen in May 2007.
To this day, Kate and Gerry have continued to hope Maddie, who would now be 20-years-old, is still alive and will one day be reunited with them.
And now German police looking for Maddie are searching a remote Portugal reservoir - an apparent favourite spot of prime suspect Christian Brueckner - in the hope of working out what happened.
Maddie's disappearance captivated the world and devastated the lives of Kate and Gerry, who dedicated themselves to finding their missing daughter.
But as the years passed by, Kate and Gerry, from Rothley, Leicestershire, had to endure the terrible juxtaposition of normal life crashing up against their ongoing trauma. They also had Amelie and Sean to keep going for.
In 2017, Gerry told the BBC: "Before Madeleine was taken, we felt we had managed to achieve our little perfect nuclear family of five.
"We had that for a short period and, almost the same way as if your child becomes ill or seriously ill, or has died, like many other families have suffered... then your vision is altered and you have to adapt.
"You adapt and you have a new normality. Unfortunately for us a new normality is a family of four. But we have adapted, that's important."
Kate added: "One of our goals – while obviously ultimately finding Madeleine – was to ensure Sean and Amelie have a very normal, happy and fulfilling life and we'll do everything that we can to ensure that."
Soon after Maddie's disappearance, Kate quit her job as a GP, such was her fear of leaving the twins with anyone else.
But in a bid to achieve 'normality', she eventually returned to work in a different capacity, admitting being busy "keeps us going".
Sadly, it is likely that neither Amelie nor Sean, who were two at the time of Maddie's disappearance, can remember their big sister.
Amelie is reportedly in the process of applying to university, and even if she can't remember Maddie, she keenly feels her big sister's absence.
In an interview with The Sun, Kate said Sean and Amelie have "grown up essentially without Madeleine but knowing their sister is missing and they want her back."
Kate previously told the Mirror ahead of her book launch that her twins gave her the strength to fight on, with Sean promising: "When you're old, me and Amelie will look for Madeleine."
She then revealed: "I was chatting to Amelie and she said, 'mummy's sad because Madeleine is not here. But Amelie is here, and Amelie and Sean will always be here'."
Speaking about their life now, Kate has told how the twins live like regular teenagers, enjoying sports and socialising.
In her ambassador role for charity Missing People, Kate said: "They have their own friends and they keep busy and they're really sporty but their only wish is for their big sister to come home. We miss our complete family of five.
"As a family 98 per cent of the time we're busy. I don't know if that's a conscious thing but it helps.
"The urge to look for Madeleine absolutely hasn't changed at all."
Both of the twins are active in the search for Maddie, and recently Amelie joined her parents and well-wishes for an anniversary event 16 years on from the disappearance.
"It's nice that everyone is here together but it's a sad occasion," she said at the event.
Student Amelie lit a candle for her big sister and other missing children at the memorial, where pictures of Maddie adorned the black railing.
Amelie then repeated mantras read out by people in the crowd, including "never never give up", "leave no stone unturned", "don't forget about me" and "still missing, still missed".
Kate and Gerry are devout Catholics, however Kate admitted her faith has been put to the test amid the trauma their family has faced.
In an extract from her 2011 book, Madeleine, Kate said: "There have been many times when I've felt God has deserted me or that He has let Madeleine down. I've occasionally doubted His existence altogether. And yes, I've been angry with Him..."
"For now, though, at least, my anger towards God seems to have subsided. I believe in Him and I still feel His presence."
The mum-of-three also stressed she believed "wherever Madeleine is, God is with her".
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