Interim manager Ralf Rangnick has a number of selection dilemmas to solve at Elland Road on Sunday afternoon.
Goals from Cristiano Ronaldo and Bruno Fernandes saw Manchester United back to winning ways against Brighton on Tuesday night - and important games continue to come thick and fast for the Old Trafford giants.
Bitter rivals Leeds United are next up for United in their ongoing quest for a place in the top four.
However, that impending Premier League showdown is also followed up three days later by the first leg of a last-16 tie with Atletico Madrid in the Champions League.
As a result, Rangnick will have some serious thinking to do before kick-off against the Whites.
Each coming with their own significance, these games can help United lay down a marker to their rivals this season.
Success in the Carabao Cup and FA Cup has already passed them by.
Indeed, their last remaining chance of silverware this campaign comes in the marquee European competition, while Arsenal, Tottenham, West Ham and surprise package Wolves have to be factored in when it comes to the tense and ongoing battle for top-four qualification.
As he ponders whether to stick or twist, Rangnick should welcome back Raphael Varane, Paul Pogba and academy graduate Marcus Rashford into his starting XI against Leeds.
Pogba and Rashford had to make do with a spot on the bench midweek, while Varane withdrew late on through illness.
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Sweden international Victor Lindelof stepped in at the 11th hour for Varane on Tuesday night.
During his latest pre-match press conference, Rangnick offered updates on Eric Bailly (ankle), Nemanja Matic (shin) and Edinson Cavani (groin and stomach). Generally that brought encouraging news, but Cavani is expected to miss out, once again, as goalkeeper Tom Heaton (stomach) encounters similar issues.
Manchester United predicted line-up vs Leeds United (4-2-3-1): De Gea; Dalot, Varane, Maguire, Telles; Pogba, McTominay; Rashford, Fernandes, Sancho; Ronaldo.
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