The largest railway strike in 30 years will begin at midnight after Tory ministers were blamed for having "actively prevented" a deal being reached.
Thousands of RMT members will walk out on Tuesday, Thursday and Saturday this week in the biggest outbreak of industrial action on the railways for a generation.
It means just five routes in Scotland will have trains running on June 21, 23, and 25 with large parts of the country cut off from the network completely.
ScotRail is not involved in the dispute but services north of the Border will still be severely disrupted as its trains rely on Network Rail staff to operate.
Labour and the SNP both accused the UK Government of deliberately picking a fight with railway workers and failing to engage a positive way with union bosses.
The RMT said its members had voted to reject offers both Network Rail and train operators.
The union is opposed to Network Rail shedding maintenance jobs and is also calling for a seven per cent wage rise.
General secretary Mick Lynch said: "The RMT National Executive Committee has now found both sets of proposals to be unacceptable and it is now confirmed that the strike action scheduled this week will go ahead.
"It is clear that the Tory Government, after slashing £4bn of funding from National Rail and Transport for London, has now actively prevented a settlement to this dispute.
"The rail companies have now proposed pay rates that are massively under the relevant rates of inflation, coming on top of the pay freezes of the past few years.
"At the behest of the Government, companies are also seeking to implement thousands of job cuts and have failed to give any guarantee against compulsory redundancies.”
Officials also claimed working practices were being changed and disputes over the role and responsibility of the guard were being restarted.
Ticket office closures were also being planned, said the RMT.
Lynch added: "Faced with such an aggressive agenda of cuts to jobs, conditions, pay and pensions, RMT has no choice but to defend our members industrially to stop this race to the bottom.
"The strikes on Network Rail, the train operators and London Underground will go ahead, and we again call on our members to stand firm, support the action, mount the pickets and demonstrate their willingness to fight for workplace justice.
"The RMT supports the campaign for a square deal for all working people in the face of the cost-of-living crisis, and our current campaign is a part of that more general campaign which means that public services have to be properly funded and all workers properly paid with good conditions.”
Downing Street said it was “deeply disappointing” that the strikes were going ahead and claimed they will not resolve the issues faced on the railways.
The Prime Minister’s official spokesman said: "This is deeply disappointing, that these disruptive, these self-defeating strikes will take place this week.
"Striking does nothing to address the long-standing issues that we need to sort to make sure our railway, that the public use and treasure, is fit for the long term."
Tory transport secretary Grant Shapps claimed there can be “no deal” without accepting the need to modernise the railways.
He told MPs: "The rhetoric we have seen from union leaders, and the Opposition benches over the weekend seems to be focused on widening the division, rather than bridging the gap.”
He said rail reform “is to unite and modernise the industry”, warning against “clinging to obsolete working practices”, giving as an example how on “most of the railway… Sunday working is voluntary”.
He said: "The industry needs to change. The union claims that this is a strike about a pay freeze, but this is factually incorrect. We are not imposing a pay freeze.
"The whole point of these reforms is in fact to build a sustainable, growing railway where every rail worker receives a decent annual pay rise.to find a solution that works for rail workers and taxpayers, and avoids causing further disruption for our passengers."
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