Rail services between Manchester and Liverpool have been hit due to a signalling failure.
Trains could be diverted, delayed or even cancelled, train company Northern announced on Thursday afternoon.
The disruption comes amid a year of rail travel chaos due to continuing industrial action by railway workers, who this week announced more strike days around Christmas after the collapse of the latest round of talks.
READ MORE: Inside Manchester's abandoned iconic building that's been left derelict for years
Announcing the disruption between Manchester and Liverpool, train company Northern tweeted: "Due to a fault with the signalling system between Liverpool Lime Street and Manchester Piccadilly the line is blocked.
"Train services running to and from these stations may be cancelled, delayed by up to 30 minutes or diverted."
Northern also tweeted that a train had broken down between Piccadilly station and Chester, leading to potential delays or cancellations. A replacement bus service was being arranged.
Earlier this week rail union RMT announced a series of 48-hour strikes on the railways in the run up to Christmas and into the New Year in a long-running dispute over jobs, pay and conditions.
More than 40,000 members of the Rail, Maritime and Transport union across Network Rail and 14 train operating companies will strike on December 13, 14, 16 and 17 and on January 3, 4, 6 and 7. They said industry bosses had failed to offer any new deals to reach a settlement.
The RMT said there would also be an overtime ban across the railways from 18 December until January 2, a step it said would mean members would be taking industrial action over a four-week period.
In a statement, the union said: "Despite every effort made by our negotiators, it is clear that that the government is directly interfering with our attempts to reach a settlement. The union suspended previous strike action in good faith to allow for intensive negotiations to resolve the dispute.
"Yet, Network Rail have failed to make an improved offer on jobs, pay and conditions for our members during the last two weeks of talks."
The news came as Prime Minister Rishi Sunak's official spokesman urged rail unions not to take further strike action, saying it would 'put the future of the rail industry in jeopardy'.
The union's statement added: "At the same time Rail Delivery Group, representing the train operating companies, have also broken a promise to make a meaningful offer on pay and conditions and even cancelled negotiations that were due to take place yesterday."
RMT general secretary, Mick Lynch, said: "This latest round of strikes will show how important our members are to the running of this country and will send a clear message that we want a good deal on job security, pay and conditions for our people.
"We have been reasonable, but it is impossible to find a negotiated settlement when the dead hand of government is presiding over these talks.
"The employers are in disarray and saying different things to different people sometimes at the same time. This whole process has become a farce that only the new Secretary of State can resolve. When I meet him later this week, I will deliver that message.
"In the meantime, our message to the public is we are sorry to inconvenience you, but we urge you to direct your anger and frustration at the government and railway employers during this latest phase of action.
"We call upon all trades unionists in Britain to take a stand and fight for better pay and conditions in their respective industries. And we will seek to coordinate strike action and demonstrations where we can. Working people across our class need a pay rise and we are determined to win that for our members in RMT."
A Rail Delivery Group spokesman said: "We made real progress over the last fortnight of talks and for the first time in months we can see the outline of a credible deal.
"Further strikes, especially in the run up to Christmas, will disrupt the first normal festive season our passengers have been able to look forward to since the Covid pandemic, taking even more money out of the pockets of railway staff, and will cause huge damage to the hospitality and retail sectors dependent on this time of the year for their businesses.
"We owe it to them to stay round the table.
"Industrial action has already cost the industry millions in lost revenue, is stalling its post-pandemic recovery and threatening its long-term sustainability. We are asking the RMT to stay at the negotiating table, work with us towards a fair deal and end a dispute that is harming passengers, the industry, and their members."
Read more of today's top stories here
READ NEXT:
- Man left fighting for his life after being stabbed in 'disturbance'
- Inside Manchester's abandoned iconic building that's been left derelict for years
- Local coffee shop's fury as Costa opens third chain in neighbourhood
- Greater Manchester Police took EIGHT hours to respond to 999 call about 'suicidal woman' who was later found dead
- Manchester United hooligans fight their OWN fans in moments ahead of Old Trafford chaos
