The RMT union confirmed it would take strike across the rail network on Saturday, October 1.
Railway workers on Network Rail and 14 train operating companies - including Avanti West Coast - will walk out as part of a long-running dispute over job security, pay and working conditions.
The 24-hour action, which will bring the railway to an effective standstill, comes after the union said it had received no further offers from the rail industry to help come to a negotiated settlement.
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Although Merseyrail workers are not part of the dispute, the ECHO understands the operator will be affected by Network Rail staff being on strike. An announcement on timetables is expected once Merseyrail and Network Rail have been able to assess the likely impact of the action.
A number of unions in various industries are also due to strike on the same date.
RMT general secretary Mick Lynch said: "Transport workers are joining a wave of strike action on October 1st, sending a clear message to the government and employers that working people will not accept continued attacks on pay and working conditions at a time when big business profits are at an all-time high.
"The summer of solidarity we have seen will continue into the autumn and winter if employers and the government continue to refuse workers reasonable demands.
"We want a settlement to these disputes where our members and their families can get a square deal. And we will not rest until we get a satisfactory outcome."
A Network Rail spokesperson said: “We have received notification of another strike by the RMT on Saturday 1 October which, coordinated with another walkout by train drivers on the same date, will mean very significant disruption for passengers – including for those travelling for the London Marathon the following day.
"We’re therefore asking all passengers to only travel if absolutely necessary on Saturday 1 October. Full timetables will be published next week.”
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