A couple of newborn puppies were found with cuts and body parts "chewed off" as they were rescued from a pile of rubbish dumped at the roadside.
The two pups who are thought to be just three days old had lacerations on their bodies and one was missing an ear as they were rushed to the vets.
The RSPCA are investigating the horrifying discovery, after the male puppy, who had lost his ear, died despite all efforts to save him.
The surviving female pup, now named Billie, is said to be doing well by her foster carer but still has to be hand-fed.
The RSPCA are sharing the tragic story of this brother and sister, who were found among flytipped rubbish in Peterborough on July 2, to launch their Cancel Out Cruelty campaign.
RSPCA Inspector Justin Stubbs, who is investigating the incident said: “We are grateful to everyone who was involved in helping these puppies.
“We would also like to thank the dedicated foster carer who is hand-rearing the female puppy - Billie.
“I’m keen to hear from anyone who may know who is responsible for abandoning these puppies in such an irresponsible way. They were so young and vulnerable."
Investigators are now appealing for information to help catch the callous culprit who left these puppies to die.
It is not yet clear what breed the puppies are, but Billie will remain in RSPCA care until she is fit and well enough for a forever home.
Mr Stubbs pleaded with people to ask for help if they are struggling financially with their pets as he highlighted the cost of living was not an excuse for abandoning animals.
He said: “We know it is a difficult time for lots of families at the moment and we understand that many are struggling to cope, particularly given the rising cost of living.
“But abandoning tiny puppies like this is so irresponsible. Please, please never abandon your pet but ask for help before things get so desperate.”