She has spent 150 days in the RSPCA's care and hasn't had a single viewing in all that time.
Poor Skye has a deformed leg, which she was likely born with, leaving staff to worry this could be one of the reasons she keeps being overlooked.
The three-year-old dog has already been through so much in her short life and was taken in by RSPCA Block Fen Animal Centre, near March, Cambridgeshire, after being abandoned.
The RSPCA say it was clear she had been used for breeding multiple litters.
Skye has been described as an "exceptionally unique girl" and as a result of her sad start to life she does require a very special home.
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Tiffany Saunders, kennel supervisor, said: “All the staff absolutely adore Skye and we want nothing more than to find her perfect forever home.
“But after 150 days and not even one meet and greet - we are all feeling really disheartened for her.
"She has had some interest over the internet - but she really has to have a very specific home and as a result we haven’t found the right person yet and so she’s not even had a meet and greet with anyone since she’s been here.
“We’ve even made a special video with all the staff and volunteers at the centre explaining why we love her so much and why she is just a one in a million dog.
“Poor Skye was just a breeding machine in her previous home so probably hasn't had the most positive experiences with humans.
“But Skye is great with people she knows once she builds the trust.
“She also has a very deformed front leg which may be a little off putting for some people - our vet believes she was born with the deformity, and they did investigate whether to amputate, however she uses the leg so much especially when running and it doesn't cause her any discomfort and she loves to have a zoomie!
“As Skye is so special and needs a specific home, we would ask people to read her profile carefully - but if you think you are a match then we would love you to get in touch.
“Skye can come across as shy to strangers, but you should see her with her handlers - she loves them! Once bonded, she will love you too, it just takes her a little bit of time to trust before she will let her guard down - which is understandable given her past.”
Skye walks well on lead however she will need to stay securely on lead at all times when out on walks, which is why it is important that she has her own large, fully secure grassed garden, where she can run free at home.
She is looking for a home where she will be the only pet, she can be choosy when it comes to four-legged friends and isn’t really the type of dog who would enjoy playing with other dogs, however she will walk alongside another as long as it didn’t hinder her.
The overlooked dog does have an unhealthy interest in cats and small animals so care would be needed around them. She needs an adult home with owners who have experience with large breeds.
Skye is extremely clever and enjoys using her brain. She soon works out what she needs to do with puzzle feeders and treat balls. She is very food focussed which is very handy when making friends with her.
An RSPCA spokesperson said: "We would very much like to be able to respond to every adoption application we receive however, at the moment this is just not possible for us to do.
"Therefore, unless your application matches the required criteria we will not be able to email you back. Thank you very much for considering adopting one of our animals. We really appreciate your kindness and support.
"If you meet all of Skye's rehoming criteria, please complete an Online Application Form. "
To help the RSPCA continue rescuing, rehabilitating and rehoming animals in desperate need of care please visit our website or call our donation line on 0300 123 8181.
Do you have a dog story to share? Email paige.freshwater@reachplc.com.