Labor leader Anthony Albanese will seek to meet with Scott Morrison to discuss any national security implications of WeChat tampering with the prime minister's account.
Mr Morrison's account on the Chinese social media platform was taken over and rebranded to "Australian Chinese new life" earlier this month, according to the Daily Telegraph.
Mr Albanese said there was real concern about any national security implications but noted the prime minister was yet to speak on the topic himself.
"I'll be seeing (Mr Morrison) this week because of the Australia Day commemorations in Canberra and I'll have a chat with him directly," the opposition leader told Brisbane radio station 4BC.
"National security should always be treated seriously, which is why I'm more than happy to have a discussion with either our (security) agencies or prime minister."
Victorian Premier Daniel Andrews said he had no issues with his account.
Labor's health spokesperson Mark Butler said the party had not heard about such concerns before and would be seeking a briefing on the issue.
"This is not a partisan issue, this is something that affects the national interest in the broadest possible sense," he said.
"We would want to seek a briefing from the government about this serious allegation and we seek as far as possible to be bipartisan and supportive of the government's attempts to repel foreign interference in our democracy."
Liberal chair of the parliamentary intelligence and security committee James Paterson said the action was sanctioned by the Chinese government and amounted to foreign interference.
"What the Chinese government has done by shutting down an Australian account is foreign interference of Australian democracy in an election year," Senator Paterson told Sydney radio station 2GB.
"It wouldn't be at all surprising if those two events were connected."
Senator Paterson called for politicians to boycott the platform.
He said the government had directly appealed to WeChat to restore access to no avail.
"A relatively small number (of politicians) are active on the platform and I think that is appropriate given that it is a surveillance and monitoring platform of overseas Chinese," Senator Paterson told Sky News.
"Now that they are attempting to make a partisan intervention by blocking one side of politics getting out a message on there, it is incumbent on all politicians to get off the platform. No politician should be legitimising their censorship."
Mr Albanese noted the Liberals had not reached out about the incident ahead of Monday morning media reports.
When asked about a boycott, Treasurer Josh Frydenberg said WeChat should restore access to the prime minister's account and allow all politicians to use the platform.
"It's something we would like to see rectified because it's a method of communication to the Australian Chinese community which is very important," he said.
"It should be on offer to politicians of all political persuasions, it shouldn't be a political football. It's very, very disappointing to see the prime minister prevented from having that access."
Senator Paterson revealed the prime minister's WeChat account has been plagued with problems for at least six months, with issues starting around the time he attended G7 meetings in the UK.
An agent running Mr Morrison's account due to the app's terms and conditions experienced trouble posting in the middle of 2021, which was around when the prime minister lobbied global government heads not to become overexposed to Chinese influence.
The initial problems came as he took a list of 14 demands handed by the Chinese embassy to an Australian journalist to the G7 to warn world leaders about the dangers of giving China too much leverage.
