Owen Farrell has reclaimed the England captaincy after completing the return to play concussion protocol and being cleared to face Argentina.
Farrell takes over from Courtney Lawes who continues to show symptoms from the head injury he suffered in September.
It is the first time he will lead England since being injured in the win over Australia at Twickenham 12 months ago.
Alex Coles will make his debut at lock in place of Lawes, with Joe Cokanasiga recalled on the left wing after losing his spot during the summer tour Down Under.
Team boss Eddie Jones said: “It’s been a really good week of preparation and I’ve been very pleased with the squad’s attitude.
“They’ve shown real work ethic and a determination to improve and our leaders, Owen, Ellis and Jack have really lifted the team.
“We’re looking forward to a great game of rugby at a full Twickenham Stadium against a very good Argentina side. It’s been a tough time for rugby lately and we hope that these autumn games show just what a special game it is.”
ENGLAND
15. Freddie Steward (Leicester Tigers, 13 caps)
14. Jack Nowell (VC) (Exeter Chiefs, 42 caps)
13. Manu Tuilagi (Sale Sharks, 46 caps)
12. Owen Farrell (C) (Saracens, 97 caps)
11. Joe Cokanasiga (Bath Rugby, 12 caps)
10. Marcus Smith (Harlequins, 13 caps)
9. Ben Youngs (Leicester Tigers, 117 caps)
1. Ellis Genge (VC) (Bristol Bears, 39 caps)
2. Luke Cowan-Dickie (Exeter Chiefs, 37 caps)
3. Kyle Sinckler (Bristol Bears, 52 caps)
4. Alex Coles (Northampton Saints, uncapped)
5. Jonny Hill (Sale Sharks, 15 caps)
6. Maro Itoje (Saracens, 58 caps)
7. Tom Curry (Sale Sharks, 41 caps)
8. Billy Vunipola (Saracens, 64 caps)
Replacements
16. Jack Singleton (Gloucester Rugby, 3 caps)
17. Mako Vunipola (Saracens, 70 caps)
18. Joe Heyes (Leicester Tigers, 5 caps)
19. David Ribbans (Northampton Saints, uncapped)
20. Sam Simmonds (Exeter Chiefs, 14 caps)
21. Jack Willis (unattached, 4 caps)
22. Jack van Poortvliet (Leicester Tigers, 3 caps)
23. Henry Slade (Exeter Chiefs, 48 caps)
