Roosters have opened their account at their new home after downing South Sydney 26-12.
Earlier, the Bulldogs came back to beat the Sea Eagles by a single point.
Check out all the news, scores and stats below.
Roosters claim first blood over Souths at new SFS
The physical intensity of the first NRL game at the new Sydney Football Stadium has taken its toll, with Sydney Roosters talisman Joey Many headlining a list of players in doubt for the first week of the finals through injury.
Manu limped from the field after tweaking his calf in a tackle midway through the second half of the Roosters' 26-16 defeat of South Sydney, following teammates Jared Waerea-Hagreaves (hamstring) and Sam Verrills (hand) to the casualty ward.
The Kiwi international has been one of the Roosters' most damaging players on their late-season surge and while on track to make the Dally M Team of the Year at centre, has proven an invaluable injury cover all around the park.
Waerea-Hargreaves missed more than a month of football with a hamstring injury earlier in the year but has since returned to form in the front row alongside Matt Lodge.
The Roosters are already without State of Origin front-rower Lindsay Collins (suspension) for the next three weeks and are likely to elevate Sio Siua Taukeiaho to the front row for the elimination final if Waerea-Hargreaves is ruled out.
The Rabbitohs weren't without injury concerns of their own.
In scenes similar to this year's third State of Origin match, captain Cameron Murray was sent for an head injury assessment just 18 seconds into Friday night's blockbuster.
Murray's head collected Kevin Naiqama's hip on the second tackle of the game, forcing him to miss the remainder of the contest.
The concussion was the lock forward's second for the year but he has also been sent for head injury assessments on two other occasions.
The NRL has not yet confirmed the draw for the first week of the finals.
But the Rabbitohs are likely to have more than seven days between games, meaning Murray should have time to clear concussion protocols.
Souths also lost Siliva Havili, who was sent for two head injury assessments.
Middle forward Hame Sele was also placed on report for a dangerous tackle.
Sele and Jai Arrow up ended Egan Butcher and drilled him head-first into the turf early in the first half.
Bulldogs secure stunning one-point victory over Sea Eagles
Manly have succumbed to their worst end to a season in club history after a late Matt Burton field goal consigned the Sea Eagles to a 21-20 loss, and their seventh straight defeat.
Down 16-0 after 20 minutes, Canterbury rallied to draw level early in the second half before Burton produced a massive final five minutes to claim the win for the Bulldogs.
The five-eighth batted back a kick to help set up a try, forced and error and then kicked a field goal with two minutes to play to snap the Dogs' own four-match losing streak.
The win will offer some hope to Canterbury fans over the summer, with new coach Cameron Ciraldo incoming and Reed Mahoney and Viliame Kikau among key signings.
"It's an awesome feeling to finish away like that," Burton told ABC Sport.
"We made it hard for ourselves there in the first half, let in some soft tries so, to come back just shows the resilience we've got here.
"To finish on a high note like that is pretty special."
Rarely has the last match of a season summed up a year like it did for Manly on Friday night.
When the Sea Eagles last won way back in mid-July, they sat eighth on the ladder and were still a genuine contender as they threatened to find form without Tom Trbojevic.
Since then though they have had their season drastically derailed by the pride jersey saga, failing to win another match and dropping their last seven for the first time in the club's 76-year history.
But for the first 20 minutes at the Sydney Olympic Stadium it was a case of "where-has-this-been" for under-pressure coach Des Hasler.
Prop Toafofoa Sipley was humming, busting through the middle to allow Daly Cherry-Evans to score Manly's first try and regularly putting the visitors beyond the advantage line.
Cherry-Evans was also firing, backing up his opening four-pointer by putting winger Christian Tuipolotu over with a nice cut-out ball.
And when departing prop Martin Taupau pushed his way through Corey Waddell to go over and make it 16-0, the more-dangerous Sea Eagles were back.
Then after completing their first 13 sets, Manly coughed up the ball in four of their next six and the Bulldogs were back in the match.
Canterbury's first came when Raymond Faitala-Mariner offloaded for Braidon Burns, before Zach Dockar-Clay had it back to 16-12 by halftime.
Aaron Schoupp then intercepted a Kieran Foran pass and when he went 90 metres to score, it was back level.
Haumole Olakau'atu briefly put Manly back in front when he chased down a Cherry-Evans grubber.
But the Sea Eagles' reprieve was short-lived, as Tevita Pangai put on a flick pass for Kyle Flanagan to level again after a Burton bat-back.
Burton then launched a massive torpedo bomb at the end of the next set, forcing an error from Manly fullback Kaeo Weekes before icing the field goal from 20 metres out to win the match.
