Nicola Bulley's family have said they are "incredibly heartbroken" after police found a body in the search for the missing mum-of-two.
The body was found around a mile from where the 45-year-old was last seen walking her dog in St Michael's on Wyre after dropping her daughters, aged six and nine, at school on January 27.
Lancashire Police said a formal identification is yet to be carried out but the mortgage adviser's family have been informed.
This evening, Sky News correspondent Inzamam Rashid said: "I've been in contact with [Nicola's family on text message, and they are heartbroken by this significant development from Lancashire Police."
He added that the family are "incredibly heartbroken" and will "really be struggling tonight."
A police spokesman said officers were called to reports of a body in the river at around 11.35am on Sunday.
"An underwater search team and specialist officers have subsequently attended the scene, entered the water and have sadly recovered a body," a statement said.
"No formal identification has yet been carried out, so we are unable to say whether this is Nicola Bulley at this time.
"Procedures to identify the body are ongoing. We are currently treating the death as unexplained.
"Nicola's family have been informed of developments and our thoughts are with them at this most difficult of times. We ask that their privacy is respected."
A tip-off from two walkers saw divers arrive at the scene as a police helicopter and drones circled overhead.
Home Secretary Suella Braverman described the developments as "heartbreaking and distressing".
She tweeted: "These are heart-breaking and distressing developments. My thoughts remain with Nicola's family at this extremely difficult time."
Peter Faulding, who assisted police in the investigation by leading a private underwater search team, wrote: "Our thoughts are with Nicola’s family and friends at this difficult time."
A man and a woman were earlier seen pointing to a spot in the River Wyre, while police drones and a helicopter hovered over an outcrop of trees and undergrowth.
A photographer at the scene told the Mirror: "It all happened so fast. Police have sealed all the roads off. It's fair to say a massive search is underway."
Police had earlier erected a tent and cordoned off the lane while police divers were called in, but the road was reopened around three hours later once the body was recovered by officers.
The area attracted press interest and members of the public including one woman who told reporters she was a clairvoyant and had "picked up" an area of the river on Saturday night.
The police diving team could be seen conducting the search while a police drone and helicopter flew above.
The investigation into Ms Bulley's disappearance has attracted widespread speculation as well as criticism of the police response.
The force came under fire after making Ms Bulley's struggles with alcohol and peri-menopause public three weeks after she vanished.
In a press conference on Wednesday, they revealed the mother-of-two was classed as a "high-risk" missing person immediately after her partner Paul Ansell reported her disappearance, "based on a number of specific vulnerabilities".
They later added in a statement that Ms Bulley, from Inskip in Lancashire, had stopped taking her HRT medication.
A public backlash and interventions from the Government and shadow home secretary Yvette Cooper followed, with Lancashire Constabulary confirming a date had been set for an internal review into the investigation.
A spokeswoman said: "A review of the investigation is diarised and will be conducted by our head of crime detective Chief Superintendent Pauline Stables."