It's hard to see any other winner than Liverpool in this one - simply because Jurgen Klopp's side have to win to remain in the title hunt.
United lost 3-1 to Liverpool early in Eddie Howe's stint in charge on a night in which questionable refereeing decisions went against them. Since then the Magpies have recovered from a relegation battle in the Premier League but this game could make or break the Reds' title tilt.
Despite having tired legs after playing in a Champions League semi-final against Villarreal just two days ago, it's hard to see Liverpool losing their grip on the title race. Although, crazy things can happen at St James' Park and that's before we even mention Dwight Gayle's record against the Reds...
Lee Ryder's prediction
I'd love to be proved wrong but this one seems a bridge too far for Newcastle in terms of making it seven wins in a row. That said there is no reason to believe United couldn't pick up a point. Erring on the side of being positive, I'll go for a high scoring draw.
Referee
Andre Marriner (West Midlands)
The man in the middle sent off Jonjo Shelvey the last time he visited St James' Park. In other officiating news the man at the centre of those ridiculous incidents at Anfield in December in Mike Dean is on VAR duty. It doesn't feel like a good combination.
Betting
#Ad: Newcastle United vs Liverpool odds with Betfred
- Newcastle United - 13/2
- Draw - 19/5
- Liverpool - 2/5
18+, new UK customers only, T&Cs apply