Israeli strikes hit Syria's Aleppo airport on Tuesday evening, damaging the runway and putting the facility out of service, the official SANA news agency said.
It is the second reported Israeli strike on the airport in northern Syria in less than a week.
"At around 8:16 pm (1716 GMT), the Israeli enemy fired missiles from the Mediterranean Sea... targeting Aleppo International Airport, damaging the runway and rendering it out of service," it said.
SANA said earlier that Syrian air defenses had intercepted some missiles, and reported material damage.
Syria's private airline Cham Wings announced that all flights to and from Aleppo would be routed to the capital Damascus due to the strikes.
The Syrian Observatory for Human Rights, a Britain-based war monitor, said several explosions were heard near Aleppo airport, "resulting from Israeli strikes on warehouses of Iran-affiliated militias".
The monitor, which has a vast network of sources on the ground in Syria, said at least two missiles destroyed the depots, causing a fire and "heavy material damage".
On Wednesday last week, SANA said Israeli strikes hit Aleppo airport, causing "some material damage".
That strike tore a hole in the runway and also damaged a structure close to the military side of the airfield, satellite photos analyzed by The Associated Press showed.
Syria’s foreign minister last week said the attack “completely destroyed the navigation station with its equipment.”
On June 10, Israeli airstrikes that struck Damascus International Airport caused significant damage to infrastructure and runways and rendered the main runway unserviceable. The airport opened two weeks later following renovation work.