Families and students have been urged to be alert for signs of invasive meningococcal disease ahead of a predicted peak in cases over coming months.
It can be deadly and up to 40 per cent of patients develop long-term consequences, according to the federal health department.
Cases usually peak in winter and early spring, with 26 recorded cases in Australia so far this year.
The number of infections dipped during the early stages of the COVID pandemic but have been on the rise in recent years, with 143 cases recorded in 2023.
The bacterial infection is spread by droplets from the nose or throat and symptoms can develop quickly with serious consequences.
Early signs can appear similar to the flu, including aches, headache and a rash.
Meningitis Centre Australia chief executive Karen Quick said children under two and those aged 15-24 were most at risk.
She said it was important for everyone to be on alert for signs of the disease particularly as people gather over school holidays, which are just beginning in some states and ending in others.
"The autumn holidays are a good reminder for all Australians to practise good hygiene practices," Ms Quick said.
"If you think you or someone you know is showing the early signs of meningococcal disease, act immediately in seeking urgent medical attention."
