Fred starts for Manchester United in the FA Cup Final against Manchester City.
The Brazilian will form a midfield three at Wembley alongside Christian Eriksen and Casemiro.
Aaron Wan-Bissaka and Luke Shaw return in defence after missing last weekend’s win over Fulham.
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Marcus Rashford leads the line, flanked by Fernandes and Jadon Sancho
Winger Antony has lost his battle to be fit. The Brazilian was carried off on a stretcher against Chelsea last week and has not recovered in time.
Anthony Martial has been ruled out due to hamstring injury and Lisandro Martinez is also out, so Victor Lindelof will partner Raphael Varane at centre-back.
Ten Hag said: “It’s about the players who are available. And every time we were successful, not every time, but a lot of times, many times, we were successful.
“So, we have a good squad and from a good squad we make a good team.”
Confirmed team news
Manchester City XI: Ortega Moreno, Walker, Stones, Dias, Akanji, Rodrigo, De Bruyne, Gundogan, Bernardo, Grealish, Haaland
Subs: Ederson, Phillips, Ake, Laporte, Alvarez, Mahrez, Foden, Palmer, Lewis
Manchester United: De Gea, Wan-Bissaka, Varane, Lindelof, Shaw, Fred, Casemiro, Eriksen, Sancho, Fernandes, Rashford
Subs: Butland, Dalot, Maguire, Malacia, McTominay, Pellistri, Elanga, Garnacho, Weghorst