Marcel Sabitzer is on the bench for Manchester United as Crystal Palace come to Old Trafford.
Jadon Sancho, who recently made his return to action, is also among the substitutes and should feature in some form.
Midfielder Sabitzer missed the midweek win over Nottingham Forest while waiting for his visa and his paperwork has now been completed ahead of welcoming Palace in the Premier League.
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Fred starts alongside Casemiro in midfield, given Christian Eriksen is set for three months out with an ankle injury.
Scott McTominay continues his spell on the sidelines and Donny van de Beek remains absent. Jack Butland is ineligible to face his parent club and Anthony Martial misses out on the squad completely.
But Diogo Dalot is back in training and he is named on the bench.
Starting XI: De Gea, Wan-Bissaka, Varane, Martinez, Shaw, Casemiro, Fred, Fernandes, Antony, Weghorst, Rashford.
Subs: Lindelof, Maguire, Malacia, Sabitzer, Dalot, Heaton, Sancho, Garnacho, Mainoo.
