Harry Maguire could return to the Manchester United side against Brighton after recovering from a knee injury but Marcus Rashford is out with bronchitis.
Maguire missed the last two games against Chelsea and Brentford with a knee problem but will be included in the travelling squad for United's penultimate game of the season.
Rashford has been ruled out and reserve centre-back Eric Bailly could also be unavailable due to a back problem. Luke Shaw has resumed individual training but is still not expected to play again this season.
Read more: West Ham stand firm on Declan Rice
"Harry is back in training," interim manager Ralf Rangnick said. "He trained the whole week since the second day after the Brentford game, so he will be available for tomorrow and part of the group.
"Edinson is in training, obviously, he came on as a substitute. Marcus Rashford will be missing, he has got bronchitis with a high temperature, so he won't be able to be part of the group and we have a question mark behind Eric Bailly, he called the doctor this morning and had some back problems and he is being checked right now. We will have to see if he will be able to train afterwards."
When asked if Maguire would regain his place in the side, Rangnick replied: "This is a decision I have to make after training today, I don't want to tell our opponents the line-up to start."
United do not play their last game of the season at Crystal Palace until May 22, leaving them with a 15-day gap after they play at Brighton. Despite Rangnick saying their Champions League qualifying chances are all but over, United could still mathematically finish fourth and, should they beat Brighton and Tottenham lose at Liverpool on Saturday evening, United would be three points behind fourth-placed Arsenal.
"I think the last two home games, we got four points against Chelsea and Brentford, we spoke about the Brentford game, it was one of our best games in possession of the ball and also one of our best games in the last six months," Rangnick added. "And I am positive the team will try to play at the same kind of level tomorrow at Brighton and in two weeks' time at Crystal Palace.
"What I liked about the game is you could see they had fun playing together, they enjoyed themselves on the pitch and this is exactly the same kind of approach we need for the game tomorrow."
