Manchester United can jump into the top four of the Premier League on Saturday evening with a win over Tottenham at Old Trafford.
That might just be a temporary measure, though, with Arsenal facing Leicester on Sunday, while they will still have three games in hand.
Spurs have a chance to breach the Champions League spots, too, but will need a four-goal lead to match the Gunners' goal difference.
Antonio Conte might be relishing a trip to Manchester after his side showed some brilliant form against Everton, where they won 5-0.
United, on the other hand, might be feeling a little limp from their 4-1 thrashing at the hands of Manchester City and are in dire need of a response.
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With Atletico Madrid coming up next Europe, it is pivotal that Ralf Rangnick gets his side back in form quickly.
"[They play] with a back three and it is a very compact shape," the German coach said.
"They are probably one of the best teams in transitional moments with Heung Min-Son and Harry Kane.
"This is what we have to be aware of and prepared for, to not give them those transitional moments. But at the same time they also lost against teams like Middlesbrough, Wolves and Burnley.
"It’s not a team who, if we play at the best possible level, it’s not impossible to beat them.
"In all respect if Middlesbrough, Burnley and Wolverhampton can beat them, we can also beat them in our own stadium and this is what we have to do, this is our job."
Rangnick has already stated that there will be changes to the starting XI and there has been much said about the right-back situation.
Aaron Wan-Bissaka had a nightmare game against City last week and Diogo Dalot has been tipped to replace him, while Rangnick has admitted that there might be a different line-up this week.
"Diogo [Dalot] has been training well this week and we have almost two players, two opponents for each position, two players who can play in that position," he added.
"With us having a couple of games coming up, one tomorrow and one on Tuesday of course it is an option to play with Diogo in one of those games."
All eyes will be on whether or not Cristiano Ronaldo will return to the team this evening at Old Trafford after missing the Manchester derby.
There are rumours that all is not well behind the scenes with the Portuguese superstar but the five-time Ballon d’Or winner is expected to start to give the Red Devils a focal point.
Raphael Varane has also returned to training this week while Marcus Rashford’s situation is still muddied amid some poor form and speculation he wants to leave this summer.
Paul Pogba has started the last four games under Rangnick while Jadon Sancho is probably United’s most in-form player right now.
Luke Shaw tested positive for Covid and Scott McTominay injured his calf, so there are serious concerns that both could miss the Atletico clash.
And there looks set to be a big change between the posts with David de Gea suspected to miss out through illness.
It means there will be a first Premier League game this season for Dean Henderson, who has had to largely sit on the bench throughout the campaign.
Man Utd (4-2-3-1): Henderson; Dalot, Varane, Maguire, Telles; Fred, Matic; Sancho, Fernandes, Pogba; Ronaldo
