Manchester United boss Erik ten Hag is set to ring the changes for his side's Europa League clash with Real Betis.
The Red Devils have a healthy advantage heading into the second leg of the Last 16 clash, having beaten the LaLiga side 4-1 at Old Trafford. With that in mind, Ten Hag has the chance to rotate his squad with an FA Cup quarter-final against Fulham ahead.
Barring a total catastrophe, they should be able to book their place in the quarter-finals of the Europa League with ease on Thursday night. But Ten Hag is likely to include several senior players to keep his side on track despite the numerous changes.
One of those senior figures should be goalkeeper David de Gea, who has impressed this season. Though he had a difficult time in the first leg against Betis, especially with his kicking, Ten Hag is likely to keep the Spaniard between the sticks.
It appears that Ten Hag has though lost confidence in Diogo Dalot, having subbed the right-back off at half-time in the first leg, then started Aaron Wan-Bissaka against Southampton.
Wan-Bissaka should then also start the second leg, as he looks to maintain his current run in the team. Raphael Varane should also keep his place at centre-back, with Ten Hag set to start with one of his regular pairing in the centre of defence.
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That means that Lisandro Martinez should drop out, with Harry Maguire expected to take the Argentine's place alongside Varane. The second of the changes in defence should come at left-back, with Tyrell Malacia replacing the rested Luke Shaw.
Ten Hag's biggest headache comes in midfield, specifically with whether or not to play Casemiro. The Brazilian was sent off against Southampton and will miss United's next four domestic games.
He is free to play in the Europa League, but is only one booking away from being suspended for one match. Ten Hag though has insisted that threat will not stop him from selecting arguably United's player of the season.
Marcel Sabizter has only just returned to training meaning that it could be a midfield duo of Casemiro and Fred. Though Bruno Fernandes is also only a booking away from suspension, Ten Hag has confirmed he will keep his place in attacking midfield.
The injury to Alejandro Garnacho is unfortunate, with the winger having been in line to start the second leg. Instead, Facundo Pellistri and Jadon Sancho should start out wide for the Red Devils, with Marcus Rashford rested while Antony was absent from training on Wednesday.
Having finally scored his first European goal for the Red Devils in the first leg, Wout Weghorstƒanto is likely to be given the chance to continue that run as United's main striker.
Predicted Manchester United line-up: David de Gea; Aaron Wan-Bissaka, Raphael Varane, Harry Maguire, Tyrell Malacia; Casemiro, Fred, Bruno Fernandes; Facundo Pellistri, Wout Weghorst, Jadon Sancho
