Manchester United kick-off the 2024/25 Premier League season at home to Fulham on Friday before Manchester City begin the defence of their title at free-spending Chelsea on Sunday.
New Liverpool manager Arne Slot will be under the spotlight on Saturday with a trip to newly-promoted Ipswich for his first competitive game since succeeding Jurgen Klopp.
AFP Sports looks at what to expect from the opening weekend of the new season:
Manchester United's shock FA Cup final win over Manchester City back in May went a long way to keeping Erik ten Hag in charge at Old Trafford.
The Dutchman has been backed by United's new football operations hierarchy, led by British billionaire Jim Ratcliffe, and was handed a contract extension to 2026.
Leny Yoro, Joshua Zirkzee, Matthijs De Ligt and Noussair Mazraoui have arrived to strengthen Ten Hag's squad for around GBP150 million ($192 million).
But after finishing eighth last season -- United's worst ever Premier League finish -- Ten Hag needs a fast start to the new campaign to dispell doubts he is the man to lead the club forward.
Fulham won at Old Trafford for the first time in 20 years in February.
Any repeat on Friday will have United fans fearing another season to forget.
Arne Slot faces a tricky start to his Premier League career when Liverpool travel to an Ipswich side back in the top-flight after a 22-year absence and buoyant after successive promotions.
Liverpool are yet to make a single signing in the transfer window but have been rampant in pre-season with eye-catching wins over Arsenal, United and Sevilla.
Victory at Portman Road would bring some relief to Liverpool fans still coming to terms with the end of Klopp's iconic reign.
The Reds could then build some momentum with a comfortable run of fixtures to come before the October international break.
But Ipswich defender Axel Tuanzebe is confident of maintaining Ipswich's proud home record over the past two seasons.
"We're going to empty the tank and give everything we've got," Tuanzebe told the BBC.
"They're just humans" he added. "It is just 11 v 11 on the pitch. Not many teams win at Portman Road and we intend to keep it that way."
New Chelsea manager Enzo Maresca has a baptism of fire against his former club.
Maresca was part of Pep Guardiola's coaching staff at City before leading Leicester to promotion from the Championship last season.
The Italian inherits a chaotic situation at Stamford Bridge with a first team squad now boasting over 50 players and question marks over the future of most of them.
Chelsea's issues were exposed in a torrid pre-season, that included a 4-2 defeat to City in the USA.
By contrast, there have been few changes for Guardiola's champions.
Brazilian winger Savinho is the only new arrival, while Argentine forward Julian Alvarez departed this week for Atletico Madrid.
City's England trio of Kyle Walker, John Stones and Phil Foden, plus Spanish midfielder Rodri, only returned to training this week after competing in the Euro 2024 final and are unlikely to start against Chelsea.
Fixtures:
Friday (all times GMT)
Manchester United v Fulham (1900)
Saturday
Ipswich v Liverpool (1130), Arsenal v Wolves, Everton v Brighton, Newcastle v Southampton, Nottingham Forest v Bournemouth (all 1400), West Ham v Aston Villa (1630)
Sunday
Brentford v Crystal Palace (1300), Chelsea v Manchester City (1530)
Monday
Leicester v Tottenham (1900)
