A motorcyclist has been rushed to hospital with a head injury following a serious crash in Stamford Hill, causing the A10 to close in both directions.
The man aged in his 20s, was taken to an east London hospital following the collision shortly after 7am on Friday.
His injuries are not life-threatening, the Met Police said.
Footage from the scene shows a motorcycle and car remain inside a large police cordon, with sand spread over an area of the road.
The road is closed both ways between Ravensdale Road and Clapton Common, creating long delays.
Congestion built up from Tottenham High Road past Seven Sisters to Tottenham Hale after the incident about 7am on Friday, Travel data site Inrix reports.
Several London bus routes are reportedly affected by the road closure.