Kirstie Alley's former co-stars Tim Allen and John Travolta lead the tributes to the actress following her death.
The Cheers actor's children True and Lillie Parker said the 71-year-old was surrounded by her closes family the moment she passed away.
She only recently discovered that she had cancer.
After hearing the news, her celebrity friends took to social media to pay tribute to the Look Who's Talking Star.
Tim, who starred alongside Kirstie in the 1997 movie For Richer or Poorer, tweeted: "A sweet soul pass on in Kristie Alley. Sad, sad news. Prayers for all her family."
Close friend John Travolta played her love interest in Look Who's Talking in 1989 and the two remained 'soulmates' ever since.
"Kirstie was one of the most special relationships I’ve ever had," he captioned an Instagram post of the two.
"I love you Kirstie. I know we will see each other again."
Her fellow Cheers co-star Ted Danson released a lengthy statement to Deadline following her death.
The actor, who played Sam Malone, said: "I was on a plane today and did something I rarely do. I watched an old episode of Cheers.
"It was the episode where Tom Berenger proposes to Kirstie, who keeps saying no, even though she desperately wants to say yes. Kirstie was truly brilliant in it. Her ability to play a woman on the verge of a nervous breakdown was both moving and hysterically funny.
"She made me laugh 30 years ago when she shot that scene, and she made me laugh today just as hard. As I got off the plane, I heard that Kirstie had died. I am so sad and so grateful for all the times she made me laugh. I send my love to her children. As they well know, their mother had a heart of gold. I will miss her."
Kelsey Grammer played Dr Frasier Crane and said: "I always believed grief for a public figure is a private matter, but I will say I loved her.”
Her death was confirmed this week in a heartbreaking statement.
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It read: "To all our friends, far and wide around the world... We are sad to inform you that our incredible, fierce and loving mother has passed away after a battle with cancer, only recently discovered.
"She was surrounded by her closest family and fought with great strength, leaving us with a certainty of her never-ending joy of living whatever adventures lie ahead. As iconic as she was on screen, she was an even more amazing mother and grandmother."
The statement went on to share the family's gratitude for those who had cared for her in her final days before praising Kirstie's attitude to life.
"We are grateful to the incredible team of doctors and nurses at the Moffitt Cancer Center for their care. Our mother's zest and passion for life, her children, grandchildren and her many animals, not to mention her eternal joy of creating, were unparalleled and leave us inspired to live life to the fullest just as she did."
They concluded by sharing their thanks for "your love and prayers".
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